Synergistic effects of CD44 and TGF-β1 through AKT/GSK-3β/β-catenin signaling during epithelial-mesenchymal transition in liver cancer cells

Cancer metastasis is strongly correlated with epithelial-mesenchymal transition (EMT), in which transforming growth factor-β (TGF-β) signaling plays a central role. CD44 has emerged as a cancer stem cell (CSC) marker that strongly induces EMT together with TGF-β1. This study aimed to investigate the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2016-09, Vol.477 (4), p.568-574
Hauptverfasser:	Park, Na Ri, Cha, Jung Hoon, Jang, Jeong Won, Bae, Si Hyun, Jang, Bohyun, Kim, Jung-Hee, Hur, Wonhee, Choi, Jong Young, Yoon, Seung Kew
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin - metabolism CD44 Cell Line, Tumor Epithelial-Mesenchymal Transition Epithelial-mesenchymal transition (EMT) Gene Knockdown Techniques Glycogen Synthase Kinase 3 beta - metabolism Hepatocellular carcinoma (HCC) Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Liver Neoplasms - enzymology Liver Neoplasms - metabolism Liver Neoplasms - pathology Metastasis Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Transforming Growth Factor beta1 - metabolism Transforming growth factor-β1 (TGF-β1)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!