Secondary forms of Takotsubo cardiomyopathy: A whole different prognosis

Background: Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification. Methods: We performed an analysis incl...

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Veröffentlicht in:European heart journal. Acute cardiovascular care 2016-08, Vol.5 (4), p.308-316
Hauptverfasser: Núñez-Gil, Iván J, Almendro-Delia, Manuel, Andrés, Mireia, Sionis, Alessandro, Martin, Ana, Bastante, Teresa, Córdoba-Soriano, Juan G, Linares, José A, González Sucarrats, Silvia, Sánchez-Grande-Flecha, Alejandro, Fabregat-Andrés, Oscar, Pérez, Beatriz, Escudier-Villa, Juan M, Martin-Reyes, Roberto, Pérez-Castellanos, Alberto, Rueda Sobella, Ferrán, Cambeiro, Cristina, Piqueras-Flores, Jesús, Vidal-Perez, Rafael, Bodí, Vicente, García de la Villa, Bernardo, Corbí-Pascua, Miguel, Biagioni, Corina, Mejía-Rentería, Hernán D, Feltes, Gisela, Barrabés, José
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container_issue 4
container_start_page 308
container_title European heart journal. Acute cardiovascular care
container_volume 5
creator Núñez-Gil, Iván J
Almendro-Delia, Manuel
Andrés, Mireia
Sionis, Alessandro
Martin, Ana
Bastante, Teresa
Córdoba-Soriano, Juan G
Linares, José A
González Sucarrats, Silvia
Sánchez-Grande-Flecha, Alejandro
Fabregat-Andrés, Oscar
Pérez, Beatriz
Escudier-Villa, Juan M
Martin-Reyes, Roberto
Pérez-Castellanos, Alberto
Rueda Sobella, Ferrán
Cambeiro, Cristina
Piqueras-Flores, Jesús
Vidal-Perez, Rafael
Bodí, Vicente
García de la Villa, Bernardo
Corbí-Pascua, Miguel
Biagioni, Corina
Mejía-Rentería, Hernán D
Feltes, Gisela
Barrabés, José
description Background: Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification. Methods: We performed an analysis including patients with TKS between 2003–2013 from our prospective local database and the RETAKO National Registry, fulfilling Mayo criteria. Patients were divided in two groups regarding their potential triggers: (a) none/psychic stress as ‘primary forms’ and (b) physical factors (asthma, surgery, trauma, etc.) as ‘secondary forms’. Results: Finally, 328 patients were included, 90.2% women, with a mean age of 69.7 years. Patients were divided into primary TKS (n=265) and 63 secondary TKS groups. Age, gender, previous functional class and cardiovascular risk profile displayed no differences between groups before admission. However, primary-TKS patients suffered a main complaint of chest pain (89.4% vs 50.7%, p
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However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification. Methods: We performed an analysis including patients with TKS between 2003–2013 from our prospective local database and the RETAKO National Registry, fulfilling Mayo criteria. Patients were divided in two groups regarding their potential triggers: (a) none/psychic stress as ‘primary forms’ and (b) physical factors (asthma, surgery, trauma, etc.) as ‘secondary forms’. Results: Finally, 328 patients were included, 90.2% women, with a mean age of 69.7 years. Patients were divided into primary TKS (n=265) and 63 secondary TKS groups. Age, gender, previous functional class and cardiovascular risk profile displayed no differences between groups before admission. However, primary-TKS patients suffered a main complaint of chest pain (89.4% vs 50.7%, p&lt;0.0001) with frequent vegetative symptoms. Regarding treatment before admission, there were no differences either. During admission, differences were related to more intensive antithrombotic and anxiolytic drug use in the primary TKS group. Inotropic and mechanical ventilation use was higher in the secondary cohort. After discharge, a more frequent prescription of beta-blockers and statins in primary-TKS patients was seen. Secondary forms displayed more in-hospital stay and evolutive complications: death (hazard ratio (HR): 3.41; 95% confidence interval (CI): 1.14–10.16, p=0.02), combined event variable (MACE) (HR: 1.61; 95% CI: 1.01–2.6, p=0.04) and recurrences (HR: 1.85; 95% CI: 1.06–3.22, p=0.02). Conclusion: Secondary TKS could present or mark worse short and long-term prognoses in terms of mortality, recurrences and readmissions. We propose a simple working nomenclature for TKS.</description><identifier>ISSN: 2048-8726</identifier><identifier>EISSN: 2048-8734</identifier><identifier>DOI: 10.1177/2048872615589512</identifier><identifier>PMID: 26045512</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Coronary Syndrome - etiology ; Acute Coronary Syndrome - pathology ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Disease Management ; Female ; Humans ; Male ; Middle Aged ; Patient Admission ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Takotsubo Cardiomyopathy - etiology ; Takotsubo Cardiomyopathy - pathology</subject><ispartof>European heart journal. Acute cardiovascular care, 2016-08, Vol.5 (4), p.308-316</ispartof><rights>The European Society of Cardiology 2015</rights><rights>The European Society of Cardiology 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-dfcb4174e2df442b15e2c4a903e3646049c676cf6e610d5ee298abb812c747dc3</citedby><cites>FETCH-LOGICAL-c473t-dfcb4174e2df442b15e2c4a903e3646049c676cf6e610d5ee298abb812c747dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2048872615589512$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2048872615589512$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26045512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Núñez-Gil, Iván J</creatorcontrib><creatorcontrib>Almendro-Delia, Manuel</creatorcontrib><creatorcontrib>Andrés, Mireia</creatorcontrib><creatorcontrib>Sionis, Alessandro</creatorcontrib><creatorcontrib>Martin, Ana</creatorcontrib><creatorcontrib>Bastante, Teresa</creatorcontrib><creatorcontrib>Córdoba-Soriano, Juan G</creatorcontrib><creatorcontrib>Linares, José A</creatorcontrib><creatorcontrib>González Sucarrats, Silvia</creatorcontrib><creatorcontrib>Sánchez-Grande-Flecha, Alejandro</creatorcontrib><creatorcontrib>Fabregat-Andrés, Oscar</creatorcontrib><creatorcontrib>Pérez, Beatriz</creatorcontrib><creatorcontrib>Escudier-Villa, Juan M</creatorcontrib><creatorcontrib>Martin-Reyes, Roberto</creatorcontrib><creatorcontrib>Pérez-Castellanos, Alberto</creatorcontrib><creatorcontrib>Rueda Sobella, Ferrán</creatorcontrib><creatorcontrib>Cambeiro, Cristina</creatorcontrib><creatorcontrib>Piqueras-Flores, Jesús</creatorcontrib><creatorcontrib>Vidal-Perez, Rafael</creatorcontrib><creatorcontrib>Bodí, Vicente</creatorcontrib><creatorcontrib>García de la Villa, Bernardo</creatorcontrib><creatorcontrib>Corbí-Pascua, Miguel</creatorcontrib><creatorcontrib>Biagioni, Corina</creatorcontrib><creatorcontrib>Mejía-Rentería, Hernán D</creatorcontrib><creatorcontrib>Feltes, Gisela</creatorcontrib><creatorcontrib>Barrabés, José</creatorcontrib><creatorcontrib>RETAKO investigators</creatorcontrib><creatorcontrib>On behalf of RETAKO investigators</creatorcontrib><title>Secondary forms of Takotsubo cardiomyopathy: A whole different prognosis</title><title>European heart journal. Acute cardiovascular care</title><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><description>Background: Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification. Methods: We performed an analysis including patients with TKS between 2003–2013 from our prospective local database and the RETAKO National Registry, fulfilling Mayo criteria. Patients were divided in two groups regarding their potential triggers: (a) none/psychic stress as ‘primary forms’ and (b) physical factors (asthma, surgery, trauma, etc.) as ‘secondary forms’. Results: Finally, 328 patients were included, 90.2% women, with a mean age of 69.7 years. Patients were divided into primary TKS (n=265) and 63 secondary TKS groups. Age, gender, previous functional class and cardiovascular risk profile displayed no differences between groups before admission. However, primary-TKS patients suffered a main complaint of chest pain (89.4% vs 50.7%, p&lt;0.0001) with frequent vegetative symptoms. Regarding treatment before admission, there were no differences either. During admission, differences were related to more intensive antithrombotic and anxiolytic drug use in the primary TKS group. Inotropic and mechanical ventilation use was higher in the secondary cohort. After discharge, a more frequent prescription of beta-blockers and statins in primary-TKS patients was seen. Secondary forms displayed more in-hospital stay and evolutive complications: death (hazard ratio (HR): 3.41; 95% confidence interval (CI): 1.14–10.16, p=0.02), combined event variable (MACE) (HR: 1.61; 95% CI: 1.01–2.6, p=0.04) and recurrences (HR: 1.85; 95% CI: 1.06–3.22, p=0.02). Conclusion: Secondary TKS could present or mark worse short and long-term prognoses in terms of mortality, recurrences and readmissions. We propose a simple working nomenclature for TKS.</description><subject>Acute Coronary Syndrome - etiology</subject><subject>Acute Coronary Syndrome - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Diagnosis, Differential</subject><subject>Disease Management</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Admission</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Takotsubo Cardiomyopathy - etiology</subject><subject>Takotsubo Cardiomyopathy - pathology</subject><issn>2048-8726</issn><issn>2048-8734</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ULFOwzAQtRCIVqU7E8rIErAdx3bYqgooUiUGyhw59rlNSeJiJ0L9e1y1MCBxy51O77279xC6JviOECHuKWZSCspJnssiJ_QMjQ-rVIqMnf_OlI_QNIQtjiUwZzK7RCPKMcsjZYwWb6BdZ5TfJ9b5NiTOJiv14fowVC7RypvatXu3U_1m_5DMkq-NayAxtbXgoeuTnXfrzoU6XKELq5oA01OfoPenx9V8kS5fn1_ms2Wqmcj61FhdMSIYUGMZoxXJgWqmCpxBxll8q9BccG05cIJNDkALqapKEqoFE0ZnE3R71I2XPwcIfdnWQUPTqA7cEEoisSgwzmQRofgI1d6F4MGWO1-30WpJcHmIsPwbYaTcnNSHqgXzS_gJLALSIyCoNZRbN_guuv1f8Bs3Hnhf</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Núñez-Gil, Iván J</creator><creator>Almendro-Delia, Manuel</creator><creator>Andrés, Mireia</creator><creator>Sionis, Alessandro</creator><creator>Martin, Ana</creator><creator>Bastante, Teresa</creator><creator>Córdoba-Soriano, Juan G</creator><creator>Linares, José A</creator><creator>González Sucarrats, Silvia</creator><creator>Sánchez-Grande-Flecha, Alejandro</creator><creator>Fabregat-Andrés, Oscar</creator><creator>Pérez, Beatriz</creator><creator>Escudier-Villa, Juan M</creator><creator>Martin-Reyes, Roberto</creator><creator>Pérez-Castellanos, Alberto</creator><creator>Rueda Sobella, Ferrán</creator><creator>Cambeiro, Cristina</creator><creator>Piqueras-Flores, Jesús</creator><creator>Vidal-Perez, Rafael</creator><creator>Bodí, Vicente</creator><creator>García de la Villa, Bernardo</creator><creator>Corbí-Pascua, Miguel</creator><creator>Biagioni, Corina</creator><creator>Mejía-Rentería, Hernán D</creator><creator>Feltes, Gisela</creator><creator>Barrabés, José</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Secondary forms of Takotsubo cardiomyopathy: A whole different prognosis</title><author>Núñez-Gil, Iván J ; Almendro-Delia, Manuel ; Andrés, Mireia ; Sionis, Alessandro ; Martin, Ana ; Bastante, Teresa ; Córdoba-Soriano, Juan G ; Linares, José A ; González Sucarrats, Silvia ; Sánchez-Grande-Flecha, Alejandro ; Fabregat-Andrés, Oscar ; Pérez, Beatriz ; Escudier-Villa, Juan M ; Martin-Reyes, Roberto ; Pérez-Castellanos, Alberto ; Rueda Sobella, Ferrán ; Cambeiro, Cristina ; Piqueras-Flores, Jesús ; Vidal-Perez, Rafael ; Bodí, Vicente ; García de la Villa, Bernardo ; Corbí-Pascua, Miguel ; Biagioni, Corina ; Mejía-Rentería, Hernán D ; Feltes, Gisela ; Barrabés, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-dfcb4174e2df442b15e2c4a903e3646049c676cf6e610d5ee298abb812c747dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Coronary Syndrome - etiology</topic><topic>Acute Coronary Syndrome - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Diagnosis, Differential</topic><topic>Disease Management</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Admission</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Takotsubo Cardiomyopathy - etiology</topic><topic>Takotsubo Cardiomyopathy - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Núñez-Gil, Iván J</creatorcontrib><creatorcontrib>Almendro-Delia, Manuel</creatorcontrib><creatorcontrib>Andrés, Mireia</creatorcontrib><creatorcontrib>Sionis, Alessandro</creatorcontrib><creatorcontrib>Martin, Ana</creatorcontrib><creatorcontrib>Bastante, Teresa</creatorcontrib><creatorcontrib>Córdoba-Soriano, Juan G</creatorcontrib><creatorcontrib>Linares, José A</creatorcontrib><creatorcontrib>González Sucarrats, Silvia</creatorcontrib><creatorcontrib>Sánchez-Grande-Flecha, Alejandro</creatorcontrib><creatorcontrib>Fabregat-Andrés, Oscar</creatorcontrib><creatorcontrib>Pérez, Beatriz</creatorcontrib><creatorcontrib>Escudier-Villa, Juan M</creatorcontrib><creatorcontrib>Martin-Reyes, Roberto</creatorcontrib><creatorcontrib>Pérez-Castellanos, Alberto</creatorcontrib><creatorcontrib>Rueda Sobella, Ferrán</creatorcontrib><creatorcontrib>Cambeiro, Cristina</creatorcontrib><creatorcontrib>Piqueras-Flores, Jesús</creatorcontrib><creatorcontrib>Vidal-Perez, Rafael</creatorcontrib><creatorcontrib>Bodí, Vicente</creatorcontrib><creatorcontrib>García de la Villa, Bernardo</creatorcontrib><creatorcontrib>Corbí-Pascua, Miguel</creatorcontrib><creatorcontrib>Biagioni, Corina</creatorcontrib><creatorcontrib>Mejía-Rentería, Hernán D</creatorcontrib><creatorcontrib>Feltes, Gisela</creatorcontrib><creatorcontrib>Barrabés, José</creatorcontrib><creatorcontrib>RETAKO investigators</creatorcontrib><creatorcontrib>On behalf of RETAKO investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal. Acute cardiovascular care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Núñez-Gil, Iván J</au><au>Almendro-Delia, Manuel</au><au>Andrés, Mireia</au><au>Sionis, Alessandro</au><au>Martin, Ana</au><au>Bastante, Teresa</au><au>Córdoba-Soriano, Juan G</au><au>Linares, José A</au><au>González Sucarrats, Silvia</au><au>Sánchez-Grande-Flecha, Alejandro</au><au>Fabregat-Andrés, Oscar</au><au>Pérez, Beatriz</au><au>Escudier-Villa, Juan M</au><au>Martin-Reyes, Roberto</au><au>Pérez-Castellanos, Alberto</au><au>Rueda Sobella, Ferrán</au><au>Cambeiro, Cristina</au><au>Piqueras-Flores, Jesús</au><au>Vidal-Perez, Rafael</au><au>Bodí, Vicente</au><au>García de la Villa, Bernardo</au><au>Corbí-Pascua, Miguel</au><au>Biagioni, Corina</au><au>Mejía-Rentería, Hernán D</au><au>Feltes, Gisela</au><au>Barrabés, José</au><aucorp>RETAKO investigators</aucorp><aucorp>On behalf of RETAKO investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary forms of Takotsubo cardiomyopathy: A whole different prognosis</atitle><jtitle>European heart journal. Acute cardiovascular care</jtitle><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>5</volume><issue>4</issue><spage>308</spage><epage>316</epage><pages>308-316</pages><issn>2048-8726</issn><eissn>2048-8734</eissn><abstract>Background: Takotsubo syndrome (TKS) usually mimics an acute coronary syndrome. However, several clinical forms have been reported. Our aim was to assess if different stressful triggers had prognostic influence on TKS, and to establish a working classification. Methods: We performed an analysis including patients with TKS between 2003–2013 from our prospective local database and the RETAKO National Registry, fulfilling Mayo criteria. Patients were divided in two groups regarding their potential triggers: (a) none/psychic stress as ‘primary forms’ and (b) physical factors (asthma, surgery, trauma, etc.) as ‘secondary forms’. Results: Finally, 328 patients were included, 90.2% women, with a mean age of 69.7 years. Patients were divided into primary TKS (n=265) and 63 secondary TKS groups. Age, gender, previous functional class and cardiovascular risk profile displayed no differences between groups before admission. However, primary-TKS patients suffered a main complaint of chest pain (89.4% vs 50.7%, p&lt;0.0001) with frequent vegetative symptoms. Regarding treatment before admission, there were no differences either. During admission, differences were related to more intensive antithrombotic and anxiolytic drug use in the primary TKS group. Inotropic and mechanical ventilation use was higher in the secondary cohort. After discharge, a more frequent prescription of beta-blockers and statins in primary-TKS patients was seen. Secondary forms displayed more in-hospital stay and evolutive complications: death (hazard ratio (HR): 3.41; 95% confidence interval (CI): 1.14–10.16, p=0.02), combined event variable (MACE) (HR: 1.61; 95% CI: 1.01–2.6, p=0.04) and recurrences (HR: 1.85; 95% CI: 1.06–3.22, p=0.02). Conclusion: Secondary TKS could present or mark worse short and long-term prognoses in terms of mortality, recurrences and readmissions. We propose a simple working nomenclature for TKS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26045512</pmid><doi>10.1177/2048872615589512</doi><tpages>9</tpages></addata></record>
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subjects Acute Coronary Syndrome - etiology
Acute Coronary Syndrome - pathology
Aged
Aged, 80 and over
Diagnosis, Differential
Disease Management
Female
Humans
Male
Middle Aged
Patient Admission
Prognosis
Proportional Hazards Models
Prospective Studies
Takotsubo Cardiomyopathy - etiology
Takotsubo Cardiomyopathy - pathology
title Secondary forms of Takotsubo cardiomyopathy: A whole different prognosis
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