Neuroprotective Effects of Dexmedetomidine Against Hypoxia-Induced Nervous System Injury are Related to Inhibition of NF-κB/COX-2 Pathways

Dexmedetomidine has been reported to provide neuroprotection against hypoxia-induced damage. However, the underlying mechanisms remain unclear. We examined whether dexmedetomidine’s neuroprotective effects were mediated by the NF-κB/COX-2 pathways. Adult male C57BL/6 mice were subjected to a 30-min...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular and molecular neurobiology 2016-10, Vol.36 (7), p.1179-1188
Hauptverfasser:	Pan, Wanying, Lin, Lin, Zhang, Nan, Yuan, Fuli, Hua, Xiaoxiao, Wang, Yueting, Mo, Liqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Caspase 3 - metabolism Cell Biology Cyclooxygenase 2 - metabolism Dexmedetomidine - pharmacokinetics Hypoxia - drug therapy Male Mice, Inbred C57BL Neurobiology Neuroprotective Agents - pharmacology Neurosciences NF-kappa B - metabolism Original Research Signal Transduction - drug effects Trauma, Nervous System - drug therapy Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!