Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Mast cells play a critical role in allergic diseases. Therefore, development of new therapeutic agents that suppresses the activation of mast cells may help prevent or treat allergic diseases. Here, we investigated the anti-allergic effects of 4-chloro-cinnamaldehyde and 4-trifluoro-cinnamaldehyde i...

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Veröffentlicht in:	International immunopharmacology 2016-09, Vol.38, p.342-348
Hauptverfasser:	Ahn, Sejin, Kim, Eunhee, Lee, Kooyeon, Lee, Deug-Chan
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-cinnamaldehyde 4-Trifluoro-cinnamaldehyde Acrolein - analogs & derivatives Acrolein - chemistry Acrolein - pharmacology Animals Cell Degranulation - drug effects Cell Line, Tumor Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Degranulation Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects Humans Hypersensitivity - drug therapy Hypersensitivity - immunology Inflammation Mediators - metabolism Interleukin-4 - genetics Interleukin-4 - metabolism Mast Cells - drug effects Mast Cells - physiology Mitogen-activated protein kinases Rats Signal Transduction - drug effects Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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