The Genetics of Transcription Factor DNA Binding Variation

Most complex trait-associated variants are located in non-coding regulatory regions of the genome, where they have been shown to disrupt transcription factor (TF)-DNA binding motifs. Variable TF-DNA interactions are therefore increasingly considered as key drivers of phenotypic variation. However, r...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell 2016-07, Vol.166 (3), p.538-554
Hauptverfasser:	Deplancke, Bart, Alpern, Daniel, Gardeux, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - metabolism Genetic Variation Humans Protein Binding - genetics Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!