Update on the pathogenesis and treatment of childhood-onset systemic lupus erythematosus

PURPOSE OF REVIEWThis article will provide an update of studies published in the last year regarding epidemiology, pathogenesis, major disease manifestations and outcomes, and therapies in childhood-onset systemic lupus erythematosus (cSLE). RECENT FINDINGSRecent studies on cSLE epidemiology support...

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Veröffentlicht in:	Current opinion in rheumatology 2016-09, Vol.28 (5), p.488-496
Hauptverfasser:	Couture, Julie, Silverman, Earl D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age of Onset Antibodies, Monoclonal, Humanized - therapeutic use Biomarkers Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - immunology Child Cyclophosphamide - therapeutic use Humans Immunity, Innate Immunologic Factors - therapeutic use Immunosuppressive Agents - therapeutic use Interleukin-1beta - genetics Lupus Erythematosus, Cutaneous - epidemiology Lupus Erythematosus, Cutaneous - etiology Lupus Erythematosus, Cutaneous - immunology Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - immunology Lupus Nephritis - drug therapy Lupus Nephritis - epidemiology Lupus Nephritis - etiology Lupus Nephritis - immunology Lupus Vasculitis, Central Nervous System - drug therapy Lupus Vasculitis, Central Nervous System - epidemiology Lupus Vasculitis, Central Nervous System - etiology Lupus Vasculitis, Central Nervous System - immunology Osteonecrosis - etiology Osteonecrosis - immunology Polymorphism, Single Nucleotide Prognosis Programmed Cell Death 1 Receptor - genetics Prospective Studies Quality of Life Rituximab - therapeutic use Severity of Illness Index Tumor Necrosis Factor-alpha - genetics Virus Diseases - immunology
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