Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina
Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal (CaMKII-α B) is altered in retinal neurons exposed to N-methyl- d-aspartate (NMDA). AIP (myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII provides neuroprotection against NMDA...
Gespeichert in:
| Veröffentlicht in: | Brain research. Molecular brain research. 2001-07, Vol.91 (1), p.34-42 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 42 |
|---|---|
| container_issue | 1 |
| container_start_page | 34 |
| container_title | Brain research. Molecular brain research. |
| container_volume | 91 |
| creator | Laabich, Aicha Li, Guangyu Cooper, Nigel G.F |
| description | Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal (CaMKII-α
B) is altered in retinal neurons exposed to
N-methyl-
d-aspartate (NMDA). AIP (myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII provides neuroprotection against NMDA-mediated neurotoxicity. In this study, gene-arrays were used to investigate which apoptosis-associated genes are altered after exposure to NMDA. The data indicate an increased expression (2–7-fold) of five such genes encoding proteins that could be involved in NMDA induced cell death. The up-regulated genes are: FasL; GADD45; GADD153; Nur77 and TNF-R1. Treatment with AIP blocked their altered expression. The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina. |
| doi_str_mv | 10.1016/S0169-328X(01)00116-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18076838</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169328X01001164</els_id><sourcerecordid>18076838</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-6366d6a499d8770c4fa9e13378bff1f9f0d85b8e3b4c3b9ab709af62d950d1953</originalsourceid><addsrcrecordid>eNqFkE1vEzEQQC0EoqHwE0A-IASHBU_W67VPqArQIhU4ABI3a9YeE6PNbmo7RfDrcZoIuPUwHsl-8-HH2GMQL0GAevW5HqZpl_rbcwEvhABQjbzDFqD7ZaOMhLts8Rc5YQ9y_iEqpQHusxMA2fXSiAXzqzUmdIVS_I0lzhOfA8ftvC1zjrn5ThNljjnPLmIhz3_GsuYfP7w54xvyhytH48g9YX2IEy9r4uh3Y-EJa1CJEz5k9wKOmR4d8yn7-u7tl9VFc_np_P3q7LJxcgmlUa1SXqE0xuu-F04GNARt2-shBAgmCK-7QVM7SNcOBodeGAxq6U0nPJiuPWXPDn23ab7aUS52E_N-PZxo3mULWvRKt7qC3QF0ac45UbDbFDeYflkQdq_X3ui1e3dWgL3Ra2Wte3IcsBvq__9VHX1W4OkRwOxwDAknF_N_3TsDRlXs9QGjauM6UrLZRZpcVZrIFevneMsmfwCKeJeE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18076838</pqid></control><display><type>article</type><title>Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Laabich, Aicha ; Li, Guangyu ; Cooper, Nigel G.F</creator><creatorcontrib>Laabich, Aicha ; Li, Guangyu ; Cooper, Nigel G.F</creatorcontrib><description>Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal (CaMKII-α
B) is altered in retinal neurons exposed to
N-methyl-
d-aspartate (NMDA). AIP (myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII provides neuroprotection against NMDA-mediated neurotoxicity. In this study, gene-arrays were used to investigate which apoptosis-associated genes are altered after exposure to NMDA. The data indicate an increased expression (2–7-fold) of five such genes encoding proteins that could be involved in NMDA induced cell death. The up-regulated genes are: FasL; GADD45; GADD153; Nur77 and TNF-R1. Treatment with AIP blocked their altered expression. The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina.</description><identifier>ISSN: 0169-328X</identifier><identifier>EISSN: 1872-6941</identifier><identifier>DOI: 10.1016/S0169-328X(01)00116-4</identifier><identifier>PMID: 11457490</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>AIP ; AIP gene ; Animals ; Antigens, CD - genetics ; Apoptosis - drug effects ; Apoptosis - genetics ; Biological and medical sciences ; CCAAT-Enhancer-Binding Proteins - genetics ; cDNA array ; DNA-Binding Proteins - genetics ; Excitatory Amino Acid Agonists - toxicity ; Eye and associated structures. Visual pathways and centers. Vision ; Fas ligand ; Fas Ligand Protein ; Female ; Fundamental and applied biological sciences. Psychology ; GADD153 protein ; GADD45 protein ; GADD45 Proteins ; Gene Expression - drug effects ; Gene Expression - physiology ; Intracellular Signaling Peptides and Proteins ; Membrane Glycoproteins - genetics ; N-Methyl-D-aspartic acid ; N-Methylaspartate - toxicity ; Neurons ; NMDA ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Nur77 protein ; Oligonucleotide Array Sequence Analysis ; Peptides - pharmacology ; Proteins - genetics ; Rat retina ; Rats ; Rats, Sprague-Dawley ; Receptors, Cytoplasmic and Nuclear ; Receptors, Steroid ; Receptors, Tumor Necrosis Factor - genetics ; Receptors, Tumor Necrosis Factor, Type I ; Retina - pathology ; Retina - physiology ; Reverse Transcriptase Polymerase Chain Reaction ; TNF-R1 protein ; Transcription Factor CHOP ; Transcription Factors - genetics ; Transcription, Genetic - drug effects ; Transcription, Genetic - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research. Molecular brain research., 2001-07, Vol.91 (1), p.34-42</ispartof><rights>2001</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-6366d6a499d8770c4fa9e13378bff1f9f0d85b8e3b4c3b9ab709af62d950d1953</citedby><cites>FETCH-LOGICAL-c421t-6366d6a499d8770c4fa9e13378bff1f9f0d85b8e3b4c3b9ab709af62d950d1953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1059196$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11457490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laabich, Aicha</creatorcontrib><creatorcontrib>Li, Guangyu</creatorcontrib><creatorcontrib>Cooper, Nigel G.F</creatorcontrib><title>Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina</title><title>Brain research. Molecular brain research.</title><addtitle>Brain Res Mol Brain Res</addtitle><description>Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal (CaMKII-α
B) is altered in retinal neurons exposed to
N-methyl-
d-aspartate (NMDA). AIP (myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII provides neuroprotection against NMDA-mediated neurotoxicity. In this study, gene-arrays were used to investigate which apoptosis-associated genes are altered after exposure to NMDA. The data indicate an increased expression (2–7-fold) of five such genes encoding proteins that could be involved in NMDA induced cell death. The up-regulated genes are: FasL; GADD45; GADD153; Nur77 and TNF-R1. Treatment with AIP blocked their altered expression. The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina.</description><subject>AIP</subject><subject>AIP gene</subject><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - genetics</subject><subject>Biological and medical sciences</subject><subject>CCAAT-Enhancer-Binding Proteins - genetics</subject><subject>cDNA array</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Excitatory Amino Acid Agonists - toxicity</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fas ligand</subject><subject>Fas Ligand Protein</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GADD153 protein</subject><subject>GADD45 protein</subject><subject>GADD45 Proteins</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - physiology</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Membrane Glycoproteins - genetics</subject><subject>N-Methyl-D-aspartic acid</subject><subject>N-Methylaspartate - toxicity</subject><subject>Neurons</subject><subject>NMDA</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 1</subject><subject>Nur77 protein</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Peptides - pharmacology</subject><subject>Proteins - genetics</subject><subject>Rat retina</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Cytoplasmic and Nuclear</subject><subject>Receptors, Steroid</subject><subject>Receptors, Tumor Necrosis Factor - genetics</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Retina - pathology</subject><subject>Retina - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>TNF-R1 protein</subject><subject>Transcription Factor CHOP</subject><subject>Transcription Factors - genetics</subject><subject>Transcription, Genetic - drug effects</subject><subject>Transcription, Genetic - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vEzEQQC0EoqHwE0A-IASHBU_W67VPqArQIhU4ABI3a9YeE6PNbmo7RfDrcZoIuPUwHsl-8-HH2GMQL0GAevW5HqZpl_rbcwEvhABQjbzDFqD7ZaOMhLts8Rc5YQ9y_iEqpQHusxMA2fXSiAXzqzUmdIVS_I0lzhOfA8ftvC1zjrn5ThNljjnPLmIhz3_GsuYfP7w54xvyhytH48g9YX2IEy9r4uh3Y-EJa1CJEz5k9wKOmR4d8yn7-u7tl9VFc_np_P3q7LJxcgmlUa1SXqE0xuu-F04GNARt2-shBAgmCK-7QVM7SNcOBodeGAxq6U0nPJiuPWXPDn23ab7aUS52E_N-PZxo3mULWvRKt7qC3QF0ac45UbDbFDeYflkQdq_X3ui1e3dWgL3Ra2Wte3IcsBvq__9VHX1W4OkRwOxwDAknF_N_3TsDRlXs9QGjauM6UrLZRZpcVZrIFevneMsmfwCKeJeE</recordid><startdate>20010713</startdate><enddate>20010713</enddate><creator>Laabich, Aicha</creator><creator>Li, Guangyu</creator><creator>Cooper, Nigel G.F</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20010713</creationdate><title>Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina</title><author>Laabich, Aicha ; Li, Guangyu ; Cooper, Nigel G.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6366d6a499d8770c4fa9e13378bff1f9f0d85b8e3b4c3b9ab709af62d950d1953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>AIP</topic><topic>AIP gene</topic><topic>Animals</topic><topic>Antigens, CD - genetics</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - genetics</topic><topic>Biological and medical sciences</topic><topic>CCAAT-Enhancer-Binding Proteins - genetics</topic><topic>cDNA array</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Excitatory Amino Acid Agonists - toxicity</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fas ligand</topic><topic>Fas Ligand Protein</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GADD153 protein</topic><topic>GADD45 protein</topic><topic>GADD45 Proteins</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - physiology</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Membrane Glycoproteins - genetics</topic><topic>N-Methyl-D-aspartic acid</topic><topic>N-Methylaspartate - toxicity</topic><topic>Neurons</topic><topic>NMDA</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 1</topic><topic>Nur77 protein</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Peptides - pharmacology</topic><topic>Proteins - genetics</topic><topic>Rat retina</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Cytoplasmic and Nuclear</topic><topic>Receptors, Steroid</topic><topic>Receptors, Tumor Necrosis Factor - genetics</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Retina - pathology</topic><topic>Retina - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>TNF-R1 protein</topic><topic>Transcription Factor CHOP</topic><topic>Transcription Factors - genetics</topic><topic>Transcription, Genetic - drug effects</topic><topic>Transcription, Genetic - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laabich, Aicha</creatorcontrib><creatorcontrib>Li, Guangyu</creatorcontrib><creatorcontrib>Cooper, Nigel G.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Brain research. Molecular brain research.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laabich, Aicha</au><au>Li, Guangyu</au><au>Cooper, Nigel G.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina</atitle><jtitle>Brain research. Molecular brain research.</jtitle><addtitle>Brain Res Mol Brain Res</addtitle><date>2001-07-13</date><risdate>2001</risdate><volume>91</volume><issue>1</issue><spage>34</spage><epage>42</epage><pages>34-42</pages><issn>0169-328X</issn><eissn>1872-6941</eissn><abstract>Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal (CaMKII-α
B) is altered in retinal neurons exposed to
N-methyl-
d-aspartate (NMDA). AIP (myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII provides neuroprotection against NMDA-mediated neurotoxicity. In this study, gene-arrays were used to investigate which apoptosis-associated genes are altered after exposure to NMDA. The data indicate an increased expression (2–7-fold) of five such genes encoding proteins that could be involved in NMDA induced cell death. The up-regulated genes are: FasL; GADD45; GADD153; Nur77 and TNF-R1. Treatment with AIP blocked their altered expression. The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11457490</pmid><doi>10.1016/S0169-328X(01)00116-4</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-328X |
| ispartof | Brain research. Molecular brain research., 2001-07, Vol.91 (1), p.34-42 |
| issn | 0169-328X 1872-6941 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18076838 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | AIP AIP gene Animals Antigens, CD - genetics Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences CCAAT-Enhancer-Binding Proteins - genetics cDNA array DNA-Binding Proteins - genetics Excitatory Amino Acid Agonists - toxicity Eye and associated structures. Visual pathways and centers. Vision Fas ligand Fas Ligand Protein Female Fundamental and applied biological sciences. Psychology GADD153 protein GADD45 protein GADD45 Proteins Gene Expression - drug effects Gene Expression - physiology Intracellular Signaling Peptides and Proteins Membrane Glycoproteins - genetics N-Methyl-D-aspartic acid N-Methylaspartate - toxicity Neurons NMDA Nuclear Receptor Subfamily 4, Group A, Member 1 Nur77 protein Oligonucleotide Array Sequence Analysis Peptides - pharmacology Proteins - genetics Rat retina Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear Receptors, Steroid Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor, Type I Retina - pathology Retina - physiology Reverse Transcriptase Polymerase Chain Reaction TNF-R1 protein Transcription Factor CHOP Transcription Factors - genetics Transcription, Genetic - drug effects Transcription, Genetic - physiology Vertebrates: nervous system and sense organs |
| title | Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T10%3A04%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20apoptosis-genes%20associated%20with%20NMDA%20mediated%20cell%20death%20in%20the%20adult%20rat%20retina&rft.jtitle=Brain%20research.%20Molecular%20brain%20research.&rft.au=Laabich,%20Aicha&rft.date=2001-07-13&rft.volume=91&rft.issue=1&rft.spage=34&rft.epage=42&rft.pages=34-42&rft.issn=0169-328X&rft.eissn=1872-6941&rft_id=info:doi/10.1016/S0169-328X(01)00116-4&rft_dat=%3Cproquest_cross%3E18076838%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18076838&rft_id=info:pmid/11457490&rft_els_id=S0169328X01001164&rfr_iscdi=true |