Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants

The plant terpene synthase (TPS) family is responsible for the biosynthesis of a variety of terpenoid natural products possessing diverse biological functions. TPSs catalyze the ionization and, most commonly, rearrangement and cyclization of prenyl diphosphate substrates, forming linear and cyclic h...

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Veröffentlicht in:	Journal of antibiotics 2016-07, Vol.69 (7), p.524-533
Hauptverfasser:	Koo, Hyun Jo, Vickery, Christopher R, Xu, Yi, Louie, Gordon V, O'Maille, Paul E, Bowman, Marianne, Nartey, Charisse M, Burkart, Michael D, Noel, Joseph P
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/45 631/535 64 82 Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Biosynthesis Catalytic Domain Enzyme Stability - genetics Hydrogen-Ion Concentration Hyoscyamus - enzymology Hyoscyamus - genetics Ionization Life Sciences Medicinal Chemistry Microbiology Mutation Organic Chemistry original-article Plant Proteins - chemistry Plant Proteins - genetics Plant Proteins - metabolism Sesquiterpenes - metabolism Temperature
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