Impact of organic mercury exposure and home delivery on neurodevelopment of Amazonian children
•Home birth is associated with decreased EtHg and increased MeHg exposures.•Neurodevelopment was not associated with birth (home vs hospital) environment.•Neurocognitive tests used were not sensitive to levels of MeHg and EtHg exposure. In the transitioning Amazon, we addressed birth environment (ho...
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| Veröffentlicht in: | International journal of hygiene and environmental health 2016-08, Vol.219 (6), p.498-502 |
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| creator | Marques, Rejane C. Bernardi, José V.E. Cunha, Mônica P.L. Dórea, José G. |
| description | •Home birth is associated with decreased EtHg and increased MeHg exposures.•Neurodevelopment was not associated with birth (home vs hospital) environment.•Neurocognitive tests used were not sensitive to levels of MeHg and EtHg exposure.
In the transitioning Amazon, we addressed birth environment (home vs hospital) and associated perinatal organic-Hg exposures: methylmercury (MeHg) from maternal fish consumption and ethylmercury (EtHg) from pediatric Thimerosal-containing vaccines (TCVs) taken systematically during hospital delivery. We studied 365 children in relation to linear growth at 60 months and neurodevelopment (milestone achievements, Bayley Scale of Infant Development/BSID at 24 months, and Stanford-Binet intelligence tests at 60 months). Mothers delivered in hospitals vs those gave birth at home had significantly (p |
| doi_str_mv | 10.1016/j.ijheh.2016.05.002 |
| format | Article |
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In the transitioning Amazon, we addressed birth environment (home vs hospital) and associated perinatal organic-Hg exposures: methylmercury (MeHg) from maternal fish consumption and ethylmercury (EtHg) from pediatric Thimerosal-containing vaccines (TCVs) taken systematically during hospital delivery. We studied 365 children in relation to linear growth at 60 months and neurodevelopment (milestone achievements, Bayley Scale of Infant Development/BSID at 24 months, and Stanford-Binet intelligence tests at 60 months). Mothers delivered in hospitals vs those gave birth at home had significantly (p<0.0001) lower hair-Hg (HHg) concentrations (12.2 vs 23.9μg/g respectively) and shorter length of breastfeeding (8.5 vs 9.7 months respectively). Home-born children had significantly (p<0.0001) higher HHg (7.1μg/g) than hospital-born children (4.6μg/g). Hospital-born children also had significantly earlier (p<0.0001) hepatitis B vaccine than home-born children (1.5 vs 24.1days respectively) and higher (p<0.0001) exposures to total TCV-EtHg (75.8 vs 49.3μg respectively). Neither anthropometric indices nor neurodevelopment (except for fluid reasoning) were directly affected by birth environment. The percentage of hospital-born children with BSID (MDI or PDI) scores <80 was not significantly different from those born at home. In spite of the differences in HHg and EtHg levels between hospital-born and home-born children, no impact on neurodevelopment was observed.</description><identifier>ISSN: 1438-4639</identifier><identifier>EISSN: 1618-131X</identifier><identifier>DOI: 10.1016/j.ijheh.2016.05.002</identifier><identifier>PMID: 27265298</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Brazil ; Breast Feeding ; Cesarean delivery ; Child Development ; Child, Preschool ; Environmental Pollutants - analysis ; Ethylmercury ; Female ; Fishes ; Food Contamination ; Hair - chemistry ; Home Childbirth ; Hospitalization ; Humans ; Intelligence Tests ; Maternal Exposure ; Mercury - analysis ; Methylmercury ; Methylmercury Compounds - analysis ; Pregnancy ; Thimerosal ; Vaccines</subject><ispartof>International journal of hygiene and environmental health, 2016-08, Vol.219 (6), p.498-502</ispartof><rights>2016 Elsevier GmbH</rights><rights>Copyright © 2016 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-382a905383d795df6aa284789cb702bf1a5f811e68ab76f60d07bbd98f6fb6093</citedby><cites>FETCH-LOGICAL-c425t-382a905383d795df6aa284789cb702bf1a5f811e68ab76f60d07bbd98f6fb6093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijheh.2016.05.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27265298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Rejane C.</creatorcontrib><creatorcontrib>Bernardi, José V.E.</creatorcontrib><creatorcontrib>Cunha, Mônica P.L.</creatorcontrib><creatorcontrib>Dórea, José G.</creatorcontrib><title>Impact of organic mercury exposure and home delivery on neurodevelopment of Amazonian children</title><title>International journal of hygiene and environmental health</title><addtitle>Int J Hyg Environ Health</addtitle><description>•Home birth is associated with decreased EtHg and increased MeHg exposures.•Neurodevelopment was not associated with birth (home vs hospital) environment.•Neurocognitive tests used were not sensitive to levels of MeHg and EtHg exposure.
In the transitioning Amazon, we addressed birth environment (home vs hospital) and associated perinatal organic-Hg exposures: methylmercury (MeHg) from maternal fish consumption and ethylmercury (EtHg) from pediatric Thimerosal-containing vaccines (TCVs) taken systematically during hospital delivery. We studied 365 children in relation to linear growth at 60 months and neurodevelopment (milestone achievements, Bayley Scale of Infant Development/BSID at 24 months, and Stanford-Binet intelligence tests at 60 months). Mothers delivered in hospitals vs those gave birth at home had significantly (p<0.0001) lower hair-Hg (HHg) concentrations (12.2 vs 23.9μg/g respectively) and shorter length of breastfeeding (8.5 vs 9.7 months respectively). Home-born children had significantly (p<0.0001) higher HHg (7.1μg/g) than hospital-born children (4.6μg/g). Hospital-born children also had significantly earlier (p<0.0001) hepatitis B vaccine than home-born children (1.5 vs 24.1days respectively) and higher (p<0.0001) exposures to total TCV-EtHg (75.8 vs 49.3μg respectively). Neither anthropometric indices nor neurodevelopment (except for fluid reasoning) were directly affected by birth environment. The percentage of hospital-born children with BSID (MDI or PDI) scores <80 was not significantly different from those born at home. In spite of the differences in HHg and EtHg levels between hospital-born and home-born children, no impact on neurodevelopment was observed.</description><subject>Animals</subject><subject>Brazil</subject><subject>Breast Feeding</subject><subject>Cesarean delivery</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Environmental Pollutants - analysis</subject><subject>Ethylmercury</subject><subject>Female</subject><subject>Fishes</subject><subject>Food Contamination</subject><subject>Hair - chemistry</subject><subject>Home Childbirth</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Intelligence Tests</subject><subject>Maternal Exposure</subject><subject>Mercury - analysis</subject><subject>Methylmercury</subject><subject>Methylmercury Compounds - analysis</subject><subject>Pregnancy</subject><subject>Thimerosal</subject><subject>Vaccines</subject><issn>1438-4639</issn><issn>1618-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P4zAQQK3VogW6-wtWQj7uJcF2Gsc-cKgQH5WQuIC0p7Uce7x1ldjBbirKryelwJHTzGjezGgeQr8pKSmh_Hxd-vUKViWbipLUJSHsGzqhnIqCVvTv9ymfV6KY80oeo9Oc1xNAiZA_0DFrGK-ZFCfo37IftNng6HBM_3XwBveQzJh2GJ6HmMcEWAeLV7EHbKHzW5haMeAAY4oWttDFoYfwtmHR65cYvA7YrHxnE4Sf6MjpLsOv9zhDj9dXD5e3xd39zfJycVeYOas3RSWYlqSuRGUbWVvHtWZi3ghp2oaw1lFdO0EpcKHbhjtOLGna1krhuGs5kdUM_TnsHVJ8GiFvVO-zga7TAeKYFRWkIY2UdI9WB9SkmHMCp4bke512ihK1F6vW6k2s2otVpFaTt2nq7P3A2PZgP2c-TE7AxQGA6c2th6Sy8RAMWJ_AbJSN_ssDr9q1i7U</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Marques, Rejane C.</creator><creator>Bernardi, José V.E.</creator><creator>Cunha, Mônica P.L.</creator><creator>Dórea, José G.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Impact of organic mercury exposure and home delivery on neurodevelopment of Amazonian children</title><author>Marques, Rejane C. ; Bernardi, José V.E. ; Cunha, Mônica P.L. ; Dórea, José G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-382a905383d795df6aa284789cb702bf1a5f811e68ab76f60d07bbd98f6fb6093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Brazil</topic><topic>Breast Feeding</topic><topic>Cesarean delivery</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>Environmental Pollutants - analysis</topic><topic>Ethylmercury</topic><topic>Female</topic><topic>Fishes</topic><topic>Food Contamination</topic><topic>Hair - chemistry</topic><topic>Home Childbirth</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Intelligence Tests</topic><topic>Maternal Exposure</topic><topic>Mercury - analysis</topic><topic>Methylmercury</topic><topic>Methylmercury Compounds - analysis</topic><topic>Pregnancy</topic><topic>Thimerosal</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Rejane C.</creatorcontrib><creatorcontrib>Bernardi, José V.E.</creatorcontrib><creatorcontrib>Cunha, Mônica P.L.</creatorcontrib><creatorcontrib>Dórea, José G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hygiene and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Rejane C.</au><au>Bernardi, José V.E.</au><au>Cunha, Mônica P.L.</au><au>Dórea, José G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of organic mercury exposure and home delivery on neurodevelopment of Amazonian children</atitle><jtitle>International journal of hygiene and environmental health</jtitle><addtitle>Int J Hyg Environ Health</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>219</volume><issue>6</issue><spage>498</spage><epage>502</epage><pages>498-502</pages><issn>1438-4639</issn><eissn>1618-131X</eissn><abstract>•Home birth is associated with decreased EtHg and increased MeHg exposures.•Neurodevelopment was not associated with birth (home vs hospital) environment.•Neurocognitive tests used were not sensitive to levels of MeHg and EtHg exposure.
In the transitioning Amazon, we addressed birth environment (home vs hospital) and associated perinatal organic-Hg exposures: methylmercury (MeHg) from maternal fish consumption and ethylmercury (EtHg) from pediatric Thimerosal-containing vaccines (TCVs) taken systematically during hospital delivery. We studied 365 children in relation to linear growth at 60 months and neurodevelopment (milestone achievements, Bayley Scale of Infant Development/BSID at 24 months, and Stanford-Binet intelligence tests at 60 months). Mothers delivered in hospitals vs those gave birth at home had significantly (p<0.0001) lower hair-Hg (HHg) concentrations (12.2 vs 23.9μg/g respectively) and shorter length of breastfeeding (8.5 vs 9.7 months respectively). Home-born children had significantly (p<0.0001) higher HHg (7.1μg/g) than hospital-born children (4.6μg/g). Hospital-born children also had significantly earlier (p<0.0001) hepatitis B vaccine than home-born children (1.5 vs 24.1days respectively) and higher (p<0.0001) exposures to total TCV-EtHg (75.8 vs 49.3μg respectively). Neither anthropometric indices nor neurodevelopment (except for fluid reasoning) were directly affected by birth environment. The percentage of hospital-born children with BSID (MDI or PDI) scores <80 was not significantly different from those born at home. In spite of the differences in HHg and EtHg levels between hospital-born and home-born children, no impact on neurodevelopment was observed.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>27265298</pmid><doi>10.1016/j.ijheh.2016.05.002</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Brazil Breast Feeding Cesarean delivery Child Development Child, Preschool Environmental Pollutants - analysis Ethylmercury Female Fishes Food Contamination Hair - chemistry Home Childbirth Hospitalization Humans Intelligence Tests Maternal Exposure Mercury - analysis Methylmercury Methylmercury Compounds - analysis Pregnancy Thimerosal Vaccines |
| title | Impact of organic mercury exposure and home delivery on neurodevelopment of Amazonian children |
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