Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice

Cardiac angiogenesis is an important determinant of heart failure. We examined the hypothesis that protein tyrosine phosphatase (PTP)-1B, a negative regulator of vascular endothelial growth factor (VEGF) receptor-2 activation, is causally involved in the cardiac microvasculature rarefaction during h...

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Veröffentlicht in:	Cardiovascular research 2016-08, Vol.111 (3), p.204-216
Hauptverfasser:	Gogiraju, Rajinikanth, Schroeter, Marco R, Bochenek, Magdalena L, Hubert, Astrid, Münzel, Thomas, Hasenfuss, Gerd, Schäfer, Katrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - physiopathology Aorta - surgery Apoptosis Arterial Pressure Caveolin 1 - metabolism Constriction Disease Models, Animal Endothelial Cells - enzymology Endothelial Cells - pathology Fibrosis Genetic Predisposition to Disease Heart Failure - enzymology Heart Failure - etiology Heart Failure - physiopathology Heart Failure - prevention & control Hindlimb Hypertrophy, Left Ventricular - enzymology Hypertrophy, Left Ventricular - physiopathology Hypertrophy, Left Ventricular - prevention & control Ischemia - enzymology Ischemia - genetics Ischemia - physiopathology Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Muscle, Skeletal - blood supply NADPH Oxidase 4 NADPH Oxidases - metabolism Neovascularization, Physiologic Nitric Oxide Synthase Type III - metabolism Phenotype Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 1 - deficiency Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Receptor, TIE-2 - metabolism Signal Transduction Time Factors Vascular Endothelial Growth Factor Receptor-2 - metabolism Ventricular Dysfunction, Left - enzymology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - prevention & control Ventricular Function, Left Ventricular Remodeling
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