Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma

Unlike 13- cis retinoic acid, the synthetic retinoid fenretinide induces apoptosis of neuroblastoma cells and in vitro acts synergistically with the chemotherapeutic drugs, cisplatin, etoposide and carboplatin. The stress-induced transcription factor GADD153 and the Bcl2-related protein Bak are upre...

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Veröffentlicht in:	Cancer letters 2003-07, Vol.197 (1), p.157-163
Hauptverfasser:	Lovat, Penny E., Oliverio, Serafina, Corazzari, Marco, Ranalli, Marco, Pearson, Andy D.J., Melino, Gerry, Piacentini, Mauro, Redfern, Christopher P.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bak bcl-2 Homologous Antagonist-Killer Protein Bcl2 Cancer Cancer therapies Carboplatin CCAAT-Enhancer-Binding Proteins - metabolism Chemotherapeutic drugs Chemotherapy Cisplatin Differentiation DNA damage Endoplasmic reticulum Endoplasmic reticulum stress Etoposide Fenretinide Fenretinide - pharmacology Free radicals GADD153 Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Medical research Membrane Proteins - metabolism N-(4-hydroxyphenyl)retinamide Neuroblastoma Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - pathology Oxidative stress Proteins Reactive oxygen Receptors, Retinoic Acid - antagonists & inhibitors Resistance Retinoic acid Retinoic acid receptor Transcription Factor CHOP Transcription factors Transcription Factors - metabolism Tumor Cells, Cultured Vitamin A
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