Reovirus as an experimental therapeutic for brain and leptomeningeal metastases from breast cancer

Brain and leptomeningeal metastases are common in breast cancer patients and our current treatments are ineffective. Reovirus type 3 is a replication competent, naturally occurring virus that usurps the activated Ras-signaling pathway (or an element thereof) of tumor cells and lyses them but leaves...

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Veröffentlicht in:	Gene therapy 2004-11, Vol.11 (21), p.1579-1589
Hauptverfasser:	Yang, WQ, Senger, DL, Lun, XQ, Muzik, H, Shi, ZQ, Dyck, RH, Norman, K, Brasher, PMA, Rewcastle, NB, George, D, Stewart, D, Lee, PWK, Forsyth, PA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Brain cancer Brain Neoplasms - secondary Brain Neoplasms - therapy Brain Neoplasms - virology Breast cancer Breast Neoplasms - therapy Cell Biology Cell Death Cell Line, Tumor Central nervous system Encephalitis Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Green Fluorescent Proteins - genetics Gynecology. Andrology. Obstetrics Health. Pharmaceutical industry Human Genetics Humans Hydrocephalus Industrial applications and implications. Economical aspects Injections, Intralesional Lethal Dose 50 Mammalian orthoreovirus 3 Mammary gland diseases Medical sciences Meningeal Neoplasms - secondary Meningeal Neoplasms - therapy Meningeal Neoplasms - virology Meninges Metastases Metastasis Mice Mice, Nude Models, Animal Nanotechnology Neoplasms, Experimental Neurology Neurotoxicity Reoviridae Infections - complications Reovirus research-article Signal transduction Transfection - methods Tumor cell lines Tumor cells Tumors Tumors of the nervous system. Phacomatoses
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