Acivicin induce filamentous growth of Saccharomyces cerevisiae

The antibiotic acivicin is a known inhibitor of g-glutamyl transpeptidase (gGTP). We found that acivicin can induce filamentous growth in both diploid and haploid cells of Saccharomyces cerevisiae. This phenomenon is not related to the inhibition of gGTP or interference in glutathione metabolism. In...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2003-10, Vol.67 (10), p.2283-2285
Hauptverfasser:	Miyake, T. (Okayama-ken. Industrial Technology Center (Japan)), Sammoto, H, Ono, B
Format:	Artikel
Sprache:	eng
Schlagworte:	acivicin ANTIBIOTICS Biological and medical sciences BREWING INDUSTRY Cell Division - drug effects DIPLOIDY Dose-Response Relationship, Drug ENZYME INHIBITORS filamentous growth Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase - antagonists & inhibitors GLUTATHIONE GROWTH CONTROL HAPLOIDY industrial strain Isoxazoles - pharmacology METABOLISM PEPTIDASES SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development yeast
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Zusammenfassung:	The antibiotic acivicin is a known inhibitor of g-glutamyl transpeptidase (gGTP). We found that acivicin can induce filamentous growth in both diploid and haploid cells of Saccharomyces cerevisiae. This phenomenon is not related to the inhibition of gGTP or interference in glutathione metabolism. Interestingly, yeasts used in the brewing industry are more sensitive to acivicin, suggesting that this dimorphological differentiation may be related to some characteristics of these particular strains.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.67.2283