The effects of endogenous interleukin-1 bioactivity on locus coeruleus neurons in response to bacterial and viral substances

In a previous study, we found that microinjection of the cytokine interleukin-1 (IL-1) into the locus coeruleus (LC) increased the electrophysiological activity of LC neurons. To determine if endogenous IL-1 similarly affects the LC, brain IL-1 was induced with lipopolysaccharide (LPS), a substance...

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Veröffentlicht in:	Brain research 2004-05, Vol.1007 (1), p.39-56
Hauptverfasser:	Borsody, Mark K., Weiss, Jay M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Analysis of Variance Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Dose-Response Relationship, Drug Drug Administration Routes Drug Interactions Female Fundamental and applied biological sciences. Psychology IL-1RA Injections, Intraperitoneal - methods Interleukin 1 Receptor Antagonist Protein Interleukin-1 Interleukin-1 - metabolism Interleukin-1 - physiology Lipopolysaccharide Lipopolysaccharides - pharmacology Locus coeruleus Locus Coeruleus - cytology Locus Coeruleus - microbiology Locus Coeruleus - virology Microinjections - methods Neurons - drug effects Neurons - microbiology Neurons - physiology Neurons - virology Peptidoglycan Peptidoglycan - pharmacology Physical Stimulation - methods Poly(I)/(C) Rats Rats, Sprague-Dawley Sialoglycoproteins - administration & dosage Time Factors Vertebrates: nervous system and sense organs
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