Repeated intracerebroventricular forskolin administration enhances behavioral sensitization to cocaine

Repeated cocaine exposure produces behavioral sensitization expressed as an increased locomotor response to subsequent drug administration. Chronic cocaine administration also results in increased activity of adenylyl cyclase and cyclic-AMP (cAMP) dependent protein kinase (PKA) in the nucleus accumb...

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Veröffentlicht in:	Behavioural brain research 2004-08, Vol.153 (1), p.255-260
Hauptverfasser:	Schroeder, Joseph A, Hummel, Michele, Unterwald, Ellen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl cyclase Analysis of Variance Animals Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences cAMP Cocaine - pharmacology Colforsin - administration & dosage Colforsin - pharmacology Dopamine Uptake Inhibitors - pharmacology Drug Administration Routes Drug Administration Schedule Drug Interactions Fundamental and applied biological sciences. Psychology Injections, Intraventricular - methods Locomotor activity Male Miscellaneous Motor Activity - drug effects Nucleus accumbens Nucleus Accumbens - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychostimulant Rats Rats, Inbred F344 Striatum Time Factors
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