Osteopontin as a Mediator of NKT Cell Function in T Cell-Mediated Liver Diseases

Both osteopontin (OPN) and natural killer T (NKT) cells play a role in the development of immunological disorders. We examined a functional link between OPN and NKT cells. Concanavalin A (Con A)-induced hepatitis is a well-characterized murine model of T cell-mediated liver diseases. Here, we show t...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2004-10, Vol.21 (4), p.539-550
Hauptverfasser:	Diao, Hongyan, Kon, Shigeyuki, Iwabuchi, Kazuya, Kimura, Chiemi, Morimoto, Junko, Ito, Daisuke, Segawa, Tatsuya, Maeda, Masahiro, Hamuro, Junji, Nakayama, Toshinori, Taniguchi, Masaru, Yagita, Hideo, Van Kaer, Luc, Onóe, Kazunori, Denhardt, David, Rittling, Susan, Uede, Toshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Antigens Blotting, Western Cell Movement Concanavalin A - pharmacology Cytokines Electrophoresis, Polyacrylamide Gel Hepatitis, Animal - chemically induced Hepatitis, Animal - immunology Immunohistochemistry Integrins - biosynthesis Integrins - immunology Killer Cells, Natural - immunology Liver Liver - immunology Liver - pathology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male Mice Models, Immunological Osteopontin Reverse Transcriptase Polymerase Chain Reaction Rodents Sialoglycoproteins - deficiency Sialoglycoproteins - immunology Signal Transduction - immunology T cell receptors T-Lymphocyte Subsets - immunology Thrombin - metabolism
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