Amino acid substitutions in Erg11p of azole-resistant Candida glabrata: Possible effective substitutions and homology modelling

[Display omitted] •Multi-azole resistance was observed in 3.3% of isolates.•The ERG11 gene harbours several previously unreported missense mutations.•Amino acid substitution G236V may be associated with fluconazole resistance according to homology modelling. Understanding the mechanisms responsible...

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Veröffentlicht in:	Journal of global antimicrobial resistance. 2016-06, Vol.5, p.42-46
Hauptverfasser:	Nabili, Mojtaba, Abdollahi Gohar, Atefeh, Badali, Hamid, Mohammadi, Rasoul, Moazeni, Maryam
Format:	Artikel
Sprache:	eng
Schlagworte:	Candida glabrata Erg11p Fluconazole Homology modelling Mutation
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