Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy
Introduction Lymphocytes are an integral part of lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI). Both LMR and PNI which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. Little evidence concerning...
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| Veröffentlicht in: | Journal of surgical oncology 2016-08, Vol.114 (2), p.202-210 |
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| creator | Wu, Si-Jia Lin, Yi-Xin Ye, Hui Li, Fu-Yu Xiong, Xian-Ze Cheng, Nan-Sheng |
| description | Introduction
Lymphocytes are an integral part of lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI). Both LMR and PNI which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. Little evidence concerning the prognostic value of LMR and PNI in hepatocellular carcinoma (HCC) patients has been published. This study aimed to investigate the prognostic value of LMR and PNI in hepatitis B virals (HBV)—associated HCC patients who underwent curative hepatectomy.
Methods
Between January 2008 and June 2013, 450 surgically treated HCC patients were retrospectively analyzed. Clinicopathological parameters, LMR and PNI were collected and compared. The multivariate analysis was performed to indentify independent prognostic factors. Overall survival (OS) and recurrence‐free survival (RFS) rates were also compared.
Results
Tumor size, vascular invasion, alpha fetoprotein level, LMR and PNI were independent prognostic factors for OS. Tumor number, tumor size, vascular invasion, LMR and PNI were independent prognostic factors for RFS. Either a high LMR or PNI could predict favorable OS and RFS in surgically treated HCC patients and vice versa.
Conclusions
Both LMR and PNI were significant independent predictors that can predict survival outcomes in HBV‐associated HCC patients who received curative hepatectomy. J. Surg. Oncol. 2016;114:202–210. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.24297 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1806077328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4121632511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5277-4a54bf9cb417b593e25932b9414caf2f023b040924183fbda80f4b73958046e03</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS0EokNhwQsgS2zKIu2144zjJR1o-RmoBEUsLcdxqIckHvwzNO_FA-Jp2i6Q2NjWPd85uvJB6DmBYwJATzbBHVNGBX-AFgTEshAg6odokTVaMC7gAD0JYQMAQizZY3RAORECgCzQn_U0bK-cnqLB0eHBjfPbq2gdVmOLt979GF2IVuMxRW_zfFQ9tmNrrrNoWqsjDsnv7C6PXYraDSZg1-Ers80p0QZ8infWp1CoEJy2Kpp2Fp02fZ965bFWXtvRDQrvPWaMAasumiyk_So7MxuMjm6YnqJHneqDeXZ7H6JvZ28vV--K9cX5-9XrdaErynnBVMWaTuiGEd5UojQ0H7QRjDCtOtoBLRtgICgjddk1raqhYw0vRVUDWxooD9HRnJv_4FcyIcrBhv3KajQuBUlqWALnJa0z-vIfdOOSzx91Q1UlZcBJpl7NlPYuBG86ufV2UH6SBOS-SpmrlDdVZvbFbWJqBtPek3fdZeBkBn7b3kz_T5Ifvl7cRRazw4Zoru8dyv-US17ySn7_fC4vP775dHpGv8hV-RfGU7w6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1805324071</pqid></control><display><type>article</type><title>Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wu, Si-Jia ; Lin, Yi-Xin ; Ye, Hui ; Li, Fu-Yu ; Xiong, Xian-Ze ; Cheng, Nan-Sheng</creator><creatorcontrib>Wu, Si-Jia ; Lin, Yi-Xin ; Ye, Hui ; Li, Fu-Yu ; Xiong, Xian-Ze ; Cheng, Nan-Sheng</creatorcontrib><description>Introduction
Lymphocytes are an integral part of lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI). Both LMR and PNI which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. Little evidence concerning the prognostic value of LMR and PNI in hepatocellular carcinoma (HCC) patients has been published. This study aimed to investigate the prognostic value of LMR and PNI in hepatitis B virals (HBV)—associated HCC patients who underwent curative hepatectomy.
Methods
Between January 2008 and June 2013, 450 surgically treated HCC patients were retrospectively analyzed. Clinicopathological parameters, LMR and PNI were collected and compared. The multivariate analysis was performed to indentify independent prognostic factors. Overall survival (OS) and recurrence‐free survival (RFS) rates were also compared.
Results
Tumor size, vascular invasion, alpha fetoprotein level, LMR and PNI were independent prognostic factors for OS. Tumor number, tumor size, vascular invasion, LMR and PNI were independent prognostic factors for RFS. Either a high LMR or PNI could predict favorable OS and RFS in surgically treated HCC patients and vice versa.
Conclusions
Both LMR and PNI were significant independent predictors that can predict survival outcomes in HBV‐associated HCC patients who received curative hepatectomy. J. Surg. Oncol. 2016;114:202–210. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.24297</identifier><identifier>PMID: 27199001</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - surgery ; Female ; Follow-Up Studies ; Forecasting ; Hepatectomy - mortality ; Hepatitis B - complications ; hepatocellular carcinoma ; Humans ; Leukocyte Count ; Liver Neoplasms - etiology ; Liver Neoplasms - mortality ; Liver Neoplasms - surgery ; liver resection ; lymphocyte to monocyte ratio ; Lymphocytes ; Male ; Middle Aged ; Monocytes ; Multivariate Analysis ; Nutrition Assessment ; Prognosis ; prognostic factor ; prognostic nutritional index ; Retrospective Studies ; Young Adult</subject><ispartof>Journal of surgical oncology, 2016-08, Vol.114 (2), p.202-210</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5277-4a54bf9cb417b593e25932b9414caf2f023b040924183fbda80f4b73958046e03</citedby><cites>FETCH-LOGICAL-c5277-4a54bf9cb417b593e25932b9414caf2f023b040924183fbda80f4b73958046e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.24297$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.24297$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27199001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Si-Jia</creatorcontrib><creatorcontrib>Lin, Yi-Xin</creatorcontrib><creatorcontrib>Ye, Hui</creatorcontrib><creatorcontrib>Li, Fu-Yu</creatorcontrib><creatorcontrib>Xiong, Xian-Ze</creatorcontrib><creatorcontrib>Cheng, Nan-Sheng</creatorcontrib><title>Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Introduction
Lymphocytes are an integral part of lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI). Both LMR and PNI which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. Little evidence concerning the prognostic value of LMR and PNI in hepatocellular carcinoma (HCC) patients has been published. This study aimed to investigate the prognostic value of LMR and PNI in hepatitis B virals (HBV)—associated HCC patients who underwent curative hepatectomy.
Methods
Between January 2008 and June 2013, 450 surgically treated HCC patients were retrospectively analyzed. Clinicopathological parameters, LMR and PNI were collected and compared. The multivariate analysis was performed to indentify independent prognostic factors. Overall survival (OS) and recurrence‐free survival (RFS) rates were also compared.
Results
Tumor size, vascular invasion, alpha fetoprotein level, LMR and PNI were independent prognostic factors for OS. Tumor number, tumor size, vascular invasion, LMR and PNI were independent prognostic factors for RFS. Either a high LMR or PNI could predict favorable OS and RFS in surgically treated HCC patients and vice versa.
Conclusions
Both LMR and PNI were significant independent predictors that can predict survival outcomes in HBV‐associated HCC patients who received curative hepatectomy. J. Surg. Oncol. 2016;114:202–210. © 2016 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forecasting</subject><subject>Hepatectomy - mortality</subject><subject>Hepatitis B - complications</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - surgery</subject><subject>liver resection</subject><subject>lymphocyte to monocyte ratio</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Multivariate Analysis</subject><subject>Nutrition Assessment</subject><subject>Prognosis</subject><subject>prognostic factor</subject><subject>prognostic nutritional index</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokNhwQsgS2zKIu2144zjJR1o-RmoBEUsLcdxqIckHvwzNO_FA-Jp2i6Q2NjWPd85uvJB6DmBYwJATzbBHVNGBX-AFgTEshAg6odokTVaMC7gAD0JYQMAQizZY3RAORECgCzQn_U0bK-cnqLB0eHBjfPbq2gdVmOLt979GF2IVuMxRW_zfFQ9tmNrrrNoWqsjDsnv7C6PXYraDSZg1-Ers80p0QZ8infWp1CoEJy2Kpp2Fp02fZ965bFWXtvRDQrvPWaMAasumiyk_So7MxuMjm6YnqJHneqDeXZ7H6JvZ28vV--K9cX5-9XrdaErynnBVMWaTuiGEd5UojQ0H7QRjDCtOtoBLRtgICgjddk1raqhYw0vRVUDWxooD9HRnJv_4FcyIcrBhv3KajQuBUlqWALnJa0z-vIfdOOSzx91Q1UlZcBJpl7NlPYuBG86ufV2UH6SBOS-SpmrlDdVZvbFbWJqBtPek3fdZeBkBn7b3kz_T5Ifvl7cRRazw4Zoru8dyv-US17ySn7_fC4vP775dHpGv8hV-RfGU7w6</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Wu, Si-Jia</creator><creator>Lin, Yi-Xin</creator><creator>Ye, Hui</creator><creator>Li, Fu-Yu</creator><creator>Xiong, Xian-Ze</creator><creator>Cheng, Nan-Sheng</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy</title><author>Wu, Si-Jia ; Lin, Yi-Xin ; Ye, Hui ; Li, Fu-Yu ; Xiong, Xian-Ze ; Cheng, Nan-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5277-4a54bf9cb417b593e25932b9414caf2f023b040924183fbda80f4b73958046e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forecasting</topic><topic>Hepatectomy - mortality</topic><topic>Hepatitis B - complications</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - surgery</topic><topic>liver resection</topic><topic>lymphocyte to monocyte ratio</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Multivariate Analysis</topic><topic>Nutrition Assessment</topic><topic>Prognosis</topic><topic>prognostic factor</topic><topic>prognostic nutritional index</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Si-Jia</creatorcontrib><creatorcontrib>Lin, Yi-Xin</creatorcontrib><creatorcontrib>Ye, Hui</creatorcontrib><creatorcontrib>Li, Fu-Yu</creatorcontrib><creatorcontrib>Xiong, Xian-Ze</creatorcontrib><creatorcontrib>Cheng, Nan-Sheng</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Si-Jia</au><au>Lin, Yi-Xin</au><au>Ye, Hui</au><au>Li, Fu-Yu</au><au>Xiong, Xian-Ze</au><au>Cheng, Nan-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>114</volume><issue>2</issue><spage>202</spage><epage>210</epage><pages>202-210</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Introduction
Lymphocytes are an integral part of lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI). Both LMR and PNI which reflect body's inflammatory and nutritional status can be obtained from routine blood and biochemical test conveniently. Little evidence concerning the prognostic value of LMR and PNI in hepatocellular carcinoma (HCC) patients has been published. This study aimed to investigate the prognostic value of LMR and PNI in hepatitis B virals (HBV)—associated HCC patients who underwent curative hepatectomy.
Methods
Between January 2008 and June 2013, 450 surgically treated HCC patients were retrospectively analyzed. Clinicopathological parameters, LMR and PNI were collected and compared. The multivariate analysis was performed to indentify independent prognostic factors. Overall survival (OS) and recurrence‐free survival (RFS) rates were also compared.
Results
Tumor size, vascular invasion, alpha fetoprotein level, LMR and PNI were independent prognostic factors for OS. Tumor number, tumor size, vascular invasion, LMR and PNI were independent prognostic factors for RFS. Either a high LMR or PNI could predict favorable OS and RFS in surgically treated HCC patients and vice versa.
Conclusions
Both LMR and PNI were significant independent predictors that can predict survival outcomes in HBV‐associated HCC patients who received curative hepatectomy. J. Surg. Oncol. 2016;114:202–210. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27199001</pmid><doi>10.1002/jso.24297</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - surgery Female Follow-Up Studies Forecasting Hepatectomy - mortality Hepatitis B - complications hepatocellular carcinoma Humans Leukocyte Count Liver Neoplasms - etiology Liver Neoplasms - mortality Liver Neoplasms - surgery liver resection lymphocyte to monocyte ratio Lymphocytes Male Middle Aged Monocytes Multivariate Analysis Nutrition Assessment Prognosis prognostic factor prognostic nutritional index Retrospective Studies Young Adult |
| title | Lymphocyte to monocyte ratio and prognostic nutritional index predict survival outcomes of hepatitis B virus-associated hepatocellular carcinoma patients after curative hepatectomy |
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