Targeting Colorectal Cancer Stem-Like Cells with Anti-CD133 Antibody-Conjugated SN-38 Nanoparticles

Cancer stem-like cells play a key role in tumor development, and these cells are relevant to the failure of conventional chemotherapy. To achieve favorable therapy for colorectal cancer, PEG–PCL-based nanoparticles, which possess good biological compatibility, were fabricated as nanocarriers for the...

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Veröffentlicht in:	ACS applied materials & interfaces 2016-07, Vol.8 (28), p.17793-17804
Hauptverfasser:	Ning, Sin-Tzu, Lee, Shin-Yu, Wei, Ming-Feng, Peng, Cheng-Liang, Lin, Susan Yun-Fan, Tsai, Ming-Hsien, Lee, Pei-Chi, Shih, Ying-Hsia, Lin, Chun-Yen, Luo, Tsai-Yueh, Shieh, Ming-Jium
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - biosynthesis AC133 Antigen - immunology Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - chemistry Colorectal Neoplasms - drug therapy Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Female HCT116 Cells HT29 Cells Humans Immunotoxins - administration & dosage Immunotoxins - chemistry Immunotoxins - immunology Mice Mice, Nude Molecular Targeted Therapy Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Random Allocation Xenograft Model Antitumor Assays
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