Analysis of a minimal Rho-GTPase circuit regulating cell shape

Networks of Rho-family GTPases regulate eukaryotic cell polarization and motility by controlling assembly and contraction of the cytoskeleton. The mutually inhibitory Rac-Rho circuit is emerging as a central, regulatory hub that can affect the shape and motility phenotype of eukaryotic cells. Recent...

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Veröffentlicht in:	Physical biology 2016-07, Vol.13 (4), p.046001-046001
Hauptverfasser:	Holmes, William R, Edelstein-Keshet, Leah
Format:	Artikel
Sprache:	eng
Schlagworte:	ameboid/mesenchymal motility Cell Movement Cell Shape Cytoskeleton - metabolism Eukaryota - cytology Eukaryota - enzymology Eukaryota - metabolism local perturbation analysis Models, Biological rac GTP-Binding Proteins - metabolism Rac-Rho rho GTP-Binding Proteins - metabolism
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