The Structure of H-2K super(b) and K super(bm8) Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance

Polymorphism within the MHC not only affects peptide specificity but also has a critical influence on the T cell repertoire; for example, the CD8 T cell response toward an immunodominant HSV glycoprotein B peptide is more diverse and of higher avidity in H-2 super(bm8) compared with H-2 super(b) mic...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-07, Vol.173 (1), p.402-409
Hauptverfasser:	Webb, Andrew I, Borg, Natalie A, Dunstone, Michelle A, Kjer-Nielsen, Lars, Beddoe, Travis, McCluskey, James, Carbone, Francis R, Bottomley, Stephen P, Aguilar, Marie-Isabel, Purcell, Anthony W, Rossjohn, Jamie
Format:	Artikel
Sprache:	eng
Schlagworte:	Herpes simplex virus
Online-Zugang:	Volltext
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