APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis

Adiponectin has been shown to suppress hepatic gluconeogenesis. However, the signaling pathways underlying its action remain ill-defined. The purpose of this study was to examine the potential role of APPL1 in mediating anti-gluconeogenic ability of adiponectin. Primary hepatocytes were isolated fro...

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Veröffentlicht in:	Molecular and cellular endocrinology 2016-09, Vol.433, p.12-19
Hauptverfasser:	Ding, Youming, Zhang, Deling, Wang, Bin, Zhang, Yemin, Wang, Lei, Chen, Xiaoyan, Li, Mingxin, Tang, Zhao, Wang, Changhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adaptor Proteins, Signal Transducing - metabolism Adiponectin Adiponectin - metabolism Animals APPL1 Gluconeogenesis Gluconeogenesis - physiology Hepatocytes - metabolism Hepatocytes - physiology Liver - metabolism Liver - physiology Male Mice Mice, Inbred C57BL Phosphorylation - physiology RNA, Messenger - metabolism Signal Transduction - physiology SirT1 STAT3 STAT3 Transcription Factor - metabolism
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