Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies

Compounds 4 and 6 possessed more potent analgesic and anti-inflammatory activities than celecoxib. Compounds 4 and 6 showed high COX-2 inhibitory efficacies almost similar to celecoxib. [Display omitted] A new series, 2-substituted mercapto-3-[2-(pyridin-2-yl)ethyl]-4(3H)-quinazolinone 1–21, was syn...

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