Loss of Cell Wall Mannosylphosphate in Candida albicans Does Not Influence Macrophage Recognition

The outer layer of the cell wall of the human pathogenic fungus Candida albicans is enriched with heavily mannosylated glycoproteins that are the immediate point of contact between the fungus and cells of the host, including phagocytes. Previous work had identified components of the acid-labile frac...

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Veröffentlicht in:	The Journal of biological chemistry 2004-09, Vol.279 (38), p.39628-39635
Hauptverfasser:	Hobson, Richard P., Munro, Carol A., Bates, Steven, MacCallum, Donna M., Cutler, Jim E., Heinsbroek, Sigrid E.M., Brown, Gordon D., Odds, Frank C., Gow, Neil A.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcian Blue Animals Candida albicans Candida albicans - genetics Candida albicans - metabolism Candida albicans - pathogenicity Candidiasis - immunology Candidiasis - microbiology Cell Line Cell Wall - metabolism Coloring Agents Female Macrophages - cytology Macrophages - immunology Macrophages - microbiology Male Mannosephosphates - metabolism Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Inbred BALB C Mutagenesis Mutation Oligosaccharides - metabolism Phosphorylation Rats Rats, Sprague-Dawley Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - immunology Virulence
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