Androgen receptors in the bonnethead, Sphyrna tiburo : cDNA cloning and tissue-specific expression in the male reproductive tract

Highlights • First major study on AR targets in male reproductive organs of a shark species. • AR mRNA and protein were detected in bonnethead testis and genital ducts. • Temporal changes in AR expression occur in association with the reproductive cycle. • Most AR targets in sharks are similar to th...

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Veröffentlicht in:	General and comparative endocrinology 2015-12, Vol.224, p.235-246
Hauptverfasser:	Tyminski, John P, Gelsleichter, James J, Motta, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Androgens - metabolism Animals Blotting, Northern Blotting, Western Cells, Cultured Cloning, Molecular DNA, Complementary - metabolism Endocrinology & Metabolism Female Humans Immunoenzyme Techniques In Situ Hybridization Leydig Cells - metabolism Male Marine Organ Specificity Ovarian Follicle - metabolism Real-Time Polymerase Chain Reaction Receptors, Androgen - genetics Receptors, Androgen - metabolism Reproduction - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sertoli Cells - metabolism Sharks Sharks - genetics Sharks - growth & development Sharks - metabolism Spermatids - metabolism Sphyrna tiburo Steroid receptors Testis Testis - metabolism
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Beschreibung
Zusammenfassung:	Highlights • First major study on AR targets in male reproductive organs of a shark species. • AR mRNA and protein were detected in bonnethead testis and genital ducts. • Temporal changes in AR expression occur in association with the reproductive cycle. • Most AR targets in sharks are similar to those reported in higher vertebrates. • Unusually high AR mRNA expression occurs in mature spermatozoa.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2015.08.018