Functional characterization of Val60, a key residue involved in the membrane-oligomerization of fragaceatoxin C, an actinoporin from Actinia fragacea

•Valine 60 is a crucial residue involved in oligomerization of actinoporins.•Mutations at this position interfere with oligomerization and reduce the overall affinity for membranes.•Actinoporin oligomerization is an enthalpy-driven process. Actinoporins are pore-forming toxins produced by different...

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