Neuroprotective effects of phytosterols and flavonoids from Cirsium setidens and Aster scaber in human brain neuroblastoma SK-N-SH cells

We investigated the neuroprotective effects and action mechanism of three major compounds [daucosterol (Dau), pectolinarin (Pec), and astragalin (Ast)] isolated from edible plants against H2O2-induced cell death of human brain neuroblastoma SK-N-SH cells. Cytotoxicity was determined by MTT and lacta...

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Veröffentlicht in:	Life sciences (1973) 2016-03, Vol.148, p.173-182
Hauptverfasser:	Chung, Mi Ja, Lee, Sanghyun, Park, Yong Il, Lee, Jisun, Kwon, Ki Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Aster Plant Aster scaber Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - prevention & control Cell Line, Tumor Cirsium Cirsium setidens Daucosterol Dose-Response Relationship, Drug Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - therapeutic use Humans Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - prevention & control Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - therapeutic use Neuroprotective effects Oxidative stress Phytosterols - chemistry Phytosterols - isolation & purification Phytosterols - therapeutic use Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - therapeutic use
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