Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)
Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation. The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol ext...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 2016-03, Vol.180, p.124-130 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 130 |
|---|---|
| container_issue | |
| container_start_page | 124 |
| container_title | Journal of ethnopharmacology |
| container_volume | 180 |
| creator | Alonso-Castro, Angel Josabad Zapata-Morales, Juan Ramón González-Chávez, Marco Martin Carranza-Álvarez, Candy Hernández-Benavides, Diego Manuel Hernández-Morales, Alejandro |
| description | Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation.
The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol extract from Costus pulverulentus stem (CPE).
The chemical characterization of CPE was performed by Gas chromatography–mass spectrometry (GC–MS). The toxicity of CPE was evaluated using the comet assay (10–1000µg/ml during 5h) and the acute toxicity test (500–5000mg/kg p.o. and i.p. during 14 days). The cytotoxic effect of CPE (1–250µg/ml) on human cancer cells was evaluated using the MTT assay. The antinociceptive effects of CPE (50–200mg/kg p.o.) were evaluated using thermal-induced nociception tests (hot plate and tail flick) and the chemical-induced nociceptive tests (acetic acid and formalin). The sedative activity of CPE (50–200mg/kg p.o.) was evaluated using the ketamine-induced sleeping time test.
CPE showed the presence of compounds such as campesterol, stigmasterol β-sitosterol, vanillic acid, among others. In the comet assay, CPE at 200µg/ml or higher concentrations induced DNA damage. In the acute toxicity test, the LD50 estimated for CPE was>5000mg/kg p.o. or i.p. CEP showed moderate cytotoxic effects on prostate carcinoma cells PC-3 cells (IC50=179±23.2µg/ml). In the chemical-induced nociception models, CPE (100 and 200mg/kg p.o.) showed antinociceptive effects with similar activity to 100mg/kg naproxen. In the thermal-induced nociception tests, CPE tested at 200mg/kg showed moderate antinociceptive effects by 28% (hot plate test) and by 25% (tail flick test). In the ketamine-induced sleeping time test, CPE showed no sedative effects.
C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2016.01.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1805507236</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874116300113</els_id><sourcerecordid>1805507236</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-89c4a96808fdd473d0d9884f05724ccff940a30c929f987180dc2ef3ab5d2bd93</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlZ_gBfZYz3sOtmvZPEkxS8oWEHPIU0mmrJtarJb7L83pdWjMDAzzPu-MA8hlxQyCrS-WWQLXGd5HDOgsegRGVLO8pRVrDgmQygYTzkr6YCchbAAAEZLOCWDvGaM11AOyevsU_qlVK51H1bJNkFjUHUhkSuddO7bKtttE2eSiQtdH5J1327Q9y2udtskS2YeQ5uMd2epUOL1OTkxsg14cegj8v5w_zZ5Sqcvj8-Tu2mqCl53KW9UKZuaAzdal6zQoBvOSwMVy0uljGlKkAWoJm9MwxnloFWOppDzSudz3RQjMt7nrr376jF0YmmDwraVK3R9ENFRVcDyoo5Supcq70LwaMTa26X0W0FB7EiKhYgkxY6kABqLRs_VIb6fL1H_OX7RRcHtXoDxyY1FL4KyuFKorY8EhXb2n_gfHS-DmQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1805507236</pqid></control><display><type>article</type><title>Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Alonso-Castro, Angel Josabad ; Zapata-Morales, Juan Ramón ; González-Chávez, Marco Martin ; Carranza-Álvarez, Candy ; Hernández-Benavides, Diego Manuel ; Hernández-Morales, Alejandro</creator><creatorcontrib>Alonso-Castro, Angel Josabad ; Zapata-Morales, Juan Ramón ; González-Chávez, Marco Martin ; Carranza-Álvarez, Candy ; Hernández-Benavides, Diego Manuel ; Hernández-Morales, Alejandro</creatorcontrib><description>Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation.
The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol extract from Costus pulverulentus stem (CPE).
The chemical characterization of CPE was performed by Gas chromatography–mass spectrometry (GC–MS). The toxicity of CPE was evaluated using the comet assay (10–1000µg/ml during 5h) and the acute toxicity test (500–5000mg/kg p.o. and i.p. during 14 days). The cytotoxic effect of CPE (1–250µg/ml) on human cancer cells was evaluated using the MTT assay. The antinociceptive effects of CPE (50–200mg/kg p.o.) were evaluated using thermal-induced nociception tests (hot plate and tail flick) and the chemical-induced nociceptive tests (acetic acid and formalin). The sedative activity of CPE (50–200mg/kg p.o.) was evaluated using the ketamine-induced sleeping time test.
CPE showed the presence of compounds such as campesterol, stigmasterol β-sitosterol, vanillic acid, among others. In the comet assay, CPE at 200µg/ml or higher concentrations induced DNA damage. In the acute toxicity test, the LD50 estimated for CPE was>5000mg/kg p.o. or i.p. CEP showed moderate cytotoxic effects on prostate carcinoma cells PC-3 cells (IC50=179±23.2µg/ml). In the chemical-induced nociception models, CPE (100 and 200mg/kg p.o.) showed antinociceptive effects with similar activity to 100mg/kg naproxen. In the thermal-induced nociception tests, CPE tested at 200mg/kg showed moderate antinociceptive effects by 28% (hot plate test) and by 25% (tail flick test). In the ketamine-induced sleeping time test, CPE showed no sedative effects.
C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2016.01.011</identifier><identifier>PMID: 26778604</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acetic Acid ; Analgesics - pharmacology ; Analgesics - therapeutic use ; Analgesics - toxicity ; Anesthetics, Dissociative - pharmacology ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Anti-Inflammatory Agents - toxicity ; Antiinflammatory ; Antinociceptive ; Cancer ; Cell Line, Tumor ; Cell Survival - drug effects ; Comet Assay ; Costaceae ; Costus ; Costus pulverulentus ; Edema - drug therapy ; Formaldehyde ; Gas chromatography–mass spectrometry ; Hot Temperature ; Humans ; Ketamine - pharmacology ; Lethal Dose 50 ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Male ; Mice, Inbred BALB C ; Pain - chemically induced ; Pain - drug therapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Plant Stems ; Toxicity</subject><ispartof>Journal of ethnopharmacology, 2016-03, Vol.180, p.124-130</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-89c4a96808fdd473d0d9884f05724ccff940a30c929f987180dc2ef3ab5d2bd93</citedby><cites>FETCH-LOGICAL-c386t-89c4a96808fdd473d0d9884f05724ccff940a30c929f987180dc2ef3ab5d2bd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874116300113$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26778604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alonso-Castro, Angel Josabad</creatorcontrib><creatorcontrib>Zapata-Morales, Juan Ramón</creatorcontrib><creatorcontrib>González-Chávez, Marco Martin</creatorcontrib><creatorcontrib>Carranza-Álvarez, Candy</creatorcontrib><creatorcontrib>Hernández-Benavides, Diego Manuel</creatorcontrib><creatorcontrib>Hernández-Morales, Alejandro</creatorcontrib><title>Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation.
The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol extract from Costus pulverulentus stem (CPE).
The chemical characterization of CPE was performed by Gas chromatography–mass spectrometry (GC–MS). The toxicity of CPE was evaluated using the comet assay (10–1000µg/ml during 5h) and the acute toxicity test (500–5000mg/kg p.o. and i.p. during 14 days). The cytotoxic effect of CPE (1–250µg/ml) on human cancer cells was evaluated using the MTT assay. The antinociceptive effects of CPE (50–200mg/kg p.o.) were evaluated using thermal-induced nociception tests (hot plate and tail flick) and the chemical-induced nociceptive tests (acetic acid and formalin). The sedative activity of CPE (50–200mg/kg p.o.) was evaluated using the ketamine-induced sleeping time test.
CPE showed the presence of compounds such as campesterol, stigmasterol β-sitosterol, vanillic acid, among others. In the comet assay, CPE at 200µg/ml or higher concentrations induced DNA damage. In the acute toxicity test, the LD50 estimated for CPE was>5000mg/kg p.o. or i.p. CEP showed moderate cytotoxic effects on prostate carcinoma cells PC-3 cells (IC50=179±23.2µg/ml). In the chemical-induced nociception models, CPE (100 and 200mg/kg p.o.) showed antinociceptive effects with similar activity to 100mg/kg naproxen. In the thermal-induced nociception tests, CPE tested at 200mg/kg showed moderate antinociceptive effects by 28% (hot plate test) and by 25% (tail flick test). In the ketamine-induced sleeping time test, CPE showed no sedative effects.
C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation.
[Display omitted]</description><subject>Acetic Acid</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Analgesics - toxicity</subject><subject>Anesthetics, Dissociative - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents - toxicity</subject><subject>Antiinflammatory</subject><subject>Antinociceptive</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Comet Assay</subject><subject>Costaceae</subject><subject>Costus</subject><subject>Costus pulverulentus</subject><subject>Edema - drug therapy</subject><subject>Formaldehyde</subject><subject>Gas chromatography–mass spectrometry</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Ketamine - pharmacology</subject><subject>Lethal Dose 50</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Male</subject><subject>Mice, Inbred BALB C</subject><subject>Pain - chemically induced</subject><subject>Pain - drug therapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>Plant Stems</subject><subject>Toxicity</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZ_gBfZYz3sOtmvZPEkxS8oWEHPIU0mmrJtarJb7L83pdWjMDAzzPu-MA8hlxQyCrS-WWQLXGd5HDOgsegRGVLO8pRVrDgmQygYTzkr6YCchbAAAEZLOCWDvGaM11AOyevsU_qlVK51H1bJNkFjUHUhkSuddO7bKtttE2eSiQtdH5J1327Q9y2udtskS2YeQ5uMd2epUOL1OTkxsg14cegj8v5w_zZ5Sqcvj8-Tu2mqCl53KW9UKZuaAzdal6zQoBvOSwMVy0uljGlKkAWoJm9MwxnloFWOppDzSudz3RQjMt7nrr376jF0YmmDwraVK3R9ENFRVcDyoo5Supcq70LwaMTa26X0W0FB7EiKhYgkxY6kABqLRs_VIb6fL1H_OX7RRcHtXoDxyY1FL4KyuFKorY8EhXb2n_gfHS-DmQ</recordid><startdate>20160302</startdate><enddate>20160302</enddate><creator>Alonso-Castro, Angel Josabad</creator><creator>Zapata-Morales, Juan Ramón</creator><creator>González-Chávez, Marco Martin</creator><creator>Carranza-Álvarez, Candy</creator><creator>Hernández-Benavides, Diego Manuel</creator><creator>Hernández-Morales, Alejandro</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20160302</creationdate><title>Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)</title><author>Alonso-Castro, Angel Josabad ; Zapata-Morales, Juan Ramón ; González-Chávez, Marco Martin ; Carranza-Álvarez, Candy ; Hernández-Benavides, Diego Manuel ; Hernández-Morales, Alejandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-89c4a96808fdd473d0d9884f05724ccff940a30c929f987180dc2ef3ab5d2bd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetic Acid</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Analgesics - toxicity</topic><topic>Anesthetics, Dissociative - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents - toxicity</topic><topic>Antiinflammatory</topic><topic>Antinociceptive</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Comet Assay</topic><topic>Costaceae</topic><topic>Costus</topic><topic>Costus pulverulentus</topic><topic>Edema - drug therapy</topic><topic>Formaldehyde</topic><topic>Gas chromatography–mass spectrometry</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Ketamine - pharmacology</topic><topic>Lethal Dose 50</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Male</topic><topic>Mice, Inbred BALB C</topic><topic>Pain - chemically induced</topic><topic>Pain - drug therapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Extracts - toxicity</topic><topic>Plant Stems</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alonso-Castro, Angel Josabad</creatorcontrib><creatorcontrib>Zapata-Morales, Juan Ramón</creatorcontrib><creatorcontrib>González-Chávez, Marco Martin</creatorcontrib><creatorcontrib>Carranza-Álvarez, Candy</creatorcontrib><creatorcontrib>Hernández-Benavides, Diego Manuel</creatorcontrib><creatorcontrib>Hernández-Morales, Alejandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alonso-Castro, Angel Josabad</au><au>Zapata-Morales, Juan Ramón</au><au>González-Chávez, Marco Martin</au><au>Carranza-Álvarez, Candy</au><au>Hernández-Benavides, Diego Manuel</au><au>Hernández-Morales, Alejandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2016-03-02</date><risdate>2016</risdate><volume>180</volume><spage>124</spage><epage>130</epage><pages>124-130</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation.
The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol extract from Costus pulverulentus stem (CPE).
The chemical characterization of CPE was performed by Gas chromatography–mass spectrometry (GC–MS). The toxicity of CPE was evaluated using the comet assay (10–1000µg/ml during 5h) and the acute toxicity test (500–5000mg/kg p.o. and i.p. during 14 days). The cytotoxic effect of CPE (1–250µg/ml) on human cancer cells was evaluated using the MTT assay. The antinociceptive effects of CPE (50–200mg/kg p.o.) were evaluated using thermal-induced nociception tests (hot plate and tail flick) and the chemical-induced nociceptive tests (acetic acid and formalin). The sedative activity of CPE (50–200mg/kg p.o.) was evaluated using the ketamine-induced sleeping time test.
CPE showed the presence of compounds such as campesterol, stigmasterol β-sitosterol, vanillic acid, among others. In the comet assay, CPE at 200µg/ml or higher concentrations induced DNA damage. In the acute toxicity test, the LD50 estimated for CPE was>5000mg/kg p.o. or i.p. CEP showed moderate cytotoxic effects on prostate carcinoma cells PC-3 cells (IC50=179±23.2µg/ml). In the chemical-induced nociception models, CPE (100 and 200mg/kg p.o.) showed antinociceptive effects with similar activity to 100mg/kg naproxen. In the thermal-induced nociception tests, CPE tested at 200mg/kg showed moderate antinociceptive effects by 28% (hot plate test) and by 25% (tail flick test). In the ketamine-induced sleeping time test, CPE showed no sedative effects.
C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>26778604</pmid><doi>10.1016/j.jep.2016.01.011</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2016-03, Vol.180, p.124-130 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1805507236 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetic Acid Analgesics - pharmacology Analgesics - therapeutic use Analgesics - toxicity Anesthetics, Dissociative - pharmacology Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents - toxicity Antiinflammatory Antinociceptive Cancer Cell Line, Tumor Cell Survival - drug effects Comet Assay Costaceae Costus Costus pulverulentus Edema - drug therapy Formaldehyde Gas chromatography–mass spectrometry Hot Temperature Humans Ketamine - pharmacology Lethal Dose 50 Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Mice, Inbred BALB C Pain - chemically induced Pain - drug therapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Extracts - toxicity Plant Stems Toxicity |
| title | Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T12%3A32%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacological%20effects%20and%20toxicity%20of%20Costus%20pulverulentus%20C.%20Presl%20(Costaceae)&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Alonso-Castro,%20Angel%20Josabad&rft.date=2016-03-02&rft.volume=180&rft.spage=124&rft.epage=130&rft.pages=124-130&rft.issn=0378-8741&rft.eissn=1872-7573&rft_id=info:doi/10.1016/j.jep.2016.01.011&rft_dat=%3Cproquest_cross%3E1805507236%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1805507236&rft_id=info:pmid/26778604&rft_els_id=S0378874116300113&rfr_iscdi=true |