Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

Clinical studies suggest a link between peripheral insulin resistance and cognitive dysfunction. Interestingly, post-mortem analyses of Alzheimer disease (AD) subjects demonstrated insulin resistance in the brain proposing a role for cognitive deficits observed in AD. However, the mechanisms respons...

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Veröffentlicht in:	Free radical biology & medicine 2016-02, Vol.91, p.127-142
Hauptverfasser:	Barone, Eugenio, Di Domenico, Fabio, Cassano, Tommaso, Arena, Andrea, Tramutola, Antonella, Lavecchia, Michele Angelo, Coccia, Raffaella, Butterfield, D. Allan, Perluigi, Marzia
Format:	Artikel
Sprache:	eng
Schlagworte:	3xTg-AD mice Aging Alzheimer disease Alzheimer Disease - enzymology Animals Biliverdin reductase-A Cell Line, Tumor Hippocampus - enzymology Humans Insulin Resistance Male Mice, 129 Strain Mice, Inbred C57BL Mice, Transgenic Oxidative Stress Oxidoreductases Acting on CH-CH Group Donors - genetics Oxidoreductases Acting on CH-CH Group Donors - metabolism Protein Processing, Post-Translational TOR Serine-Threonine Kinases - metabolism Tumor Necrosis Factor-alpha - metabolism
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