Alleviation of renal mitochondrial dysfunction and apoptosis underlies the protective effect of sitagliptin in gentamicin-induced nephrotoxicity

Objective This study aimed to investigate the potential protective effect of sitagliptin on gentamicin‐induced nephrotoxicity and to elucidate the underlying mechanism. Methods Wistar rats were allocated as follows: Gentamicin group: received gentamicin intraperitoneally (100 mg/kg/day); Gentamicin...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2016-04, Vol.68 (4), p.523-532
Hauptverfasser:	Abuelezz, Sally A., Hendawy, Nevien, Abdel Gawad, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Biomarkers - blood Blood Glucose - drug effects Blood Glucose - metabolism Blood Urea Nitrogen Creatinine - blood Cytoprotection Dehydrogenases Disease Models, Animal Electron Transport - drug effects Energy Metabolism - drug effects gentamicin Gentamicins Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Lipid Peroxidation - drug effects Male Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA mitochondrial dysfunction nephrotoxicity Oxidative stress Oxidative Stress - drug effects Proteinuria - chemically induced Proteinuria - metabolism Proteinuria - prevention & control Rats, Wistar Rodents sitagliptin Sitagliptin Phosphate - pharmacology Urine
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