Nanoparticle transport across in vitro olfactory cell monolayers

[Display omitted] Drug access to the CNS is hindered by the presence of the blood–brain barrier (BBB), and the intranasal route has risen as a non-invasive route to transport drugs directly from nose-to-brain avoiding the BBB. In addition, nanoparticles (NPs) have been described as efficient shuttle...

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Veröffentlicht in:	International journal of pharmaceutics 2016-02, Vol.499 (1-2), p.81-89
Hauptverfasser:	Gartziandia, Oihane, Egusquiaguirre, Susana Patricia, Bianco, John, Pedraz, José Luis, Igartua, Manoli, Hernandez, Rosa Maria, Préat, Véronique, Beloqui, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Biological Transport Blood-Brain Barrier - metabolism Brain - metabolism Cell-Penetrating Peptides - chemistry Chemistry, Pharmaceutical - methods Chitosan - chemistry CPP Drug Delivery Systems Female Lactic Acid - chemistry Lipid nanoparticles Lipids - chemistry Nanoparticles NLC Nose - metabolism Nose-to-brain delivery Olfactory mucosa Olfactory Mucosa - cytology Olfactory Mucosa - metabolism Polyglycolic Acid - chemistry Polymers - chemistry Rats Rats, Wistar
Online-Zugang:	Volltext
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