The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level
Objective In patients with rheumatoid arthritis (RA), bone marrow edema (BME) scores are associated with development of erosions. However, little is known about the course and outcome of BME at bone level. We undertook this study to determine the association of BME and synovitis with the development...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2016-05, Vol.68 (5), p.1080-1088 |
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| creator | Nieuwenhuis, Wouter P. van Steenbergen, Hanna W. Stomp, Wouter Stijnen, Theo Huizinga, Tom W. J. Bloem, Johan L. van der Heijde, Désirée Reijnierse, Monique van der Helm‐van Mil, Annette H. M. |
| description | Objective
In patients with rheumatoid arthritis (RA), bone marrow edema (BME) scores are associated with development of erosions. However, little is known about the course and outcome of BME at bone level. We undertook this study to determine the association of BME and synovitis with the development of erosions in the same bone longitudinally.
Methods
Using 1.5T magnetic resonance imaging at baseline and at 4‐ and 12‐month follow‐up, we studied 1,947 bones of the metacarpophalangeal, wrist, and metatarsophalangeal joints in 59 patients presenting with RA or undifferentiated arthritis. Scanning and scoring of BME, synovitis, and erosions were performed according to the Outcome Measures in Rheumatology Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system. We evaluated the relationship of the course of BME and synovitis with erosive progression at bone level during 1 year.
Results
Of the bones showing BME at baseline (n = 203), BME persisted in 56%, disappeared in 39%, and disappeared and then reappeared in 5%. Stratified analyses at baseline revealed that BME was associated with erosive progression both in the presence and in the absence of local synovitis, with odds ratios (ORs) of 7.5 (95% confidence interval [95% CI] 3.8–14.9) and 6.9 (95% CI 1.9–25.6), respectively. However, local synovitis was not associated with erosive progression in the presence or in the absence of BME (ORs of 2.0 [95% CI 0.6–7.0] and 1.9 [95% CI 0.8–4.1], respectively). In multivariable generalized estimating equation analyses, persistent BME was strongly associated with erosive progression (OR 60.5 [95% CI 16.8–218.1]) in contrast to persistent synovitis (OR 1.3 [95% CI 0.4–4.4]).
Conclusion
BME frequently persists during the first year. Persistent BME was strongly associated with erosive progression in the same bone, independently of local synovitis. No independent association was observed for persistent synovitis. These findings are relevant for comprehending the development of erosions in RA. |
| doi_str_mv | 10.1002/art.39550 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1805500264</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4036520211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4870-a6634dce0156ddd8d046c1ba8f71f2645399c01299158eaae15d49829499b9743</originalsourceid><addsrcrecordid>eNqFkdFqFDEUhgdRbKm98AUk4I1ebHsyk2QS77bLthZWhHV7PWQnZ3ZTZpKaZCz7LL6saacVEcTcnMD5-Dj8f1G8pXBGAcpzHdJZpTiHF8VxWZVixkvgL5__VNGj4jTGW8hP1SCAvy6OSiEkBSmOi5-bPZKFH0NE4jty4R2SLzoEf0-WBgdNrCNLHfoDuXHGdh0GdMnqhIbMQ9oHm2wk2hmy3uM46OTtH4tPZE5W3u1sGo11us_mncNkW7LG6J12LZLrQe-s25FvmTkQnaYTVvgD-zfFq073EU-f5klxc7ncLD7PVl-vrhfz1axlsoaZFqJipkWgXBhjpAEmWrrVsqtpVwrGK6VaoKVSlEvUGik3TMlSMaW2qmbVSfFh8t4F_33EmJrBxhb7Xjv0Y2yohBwvZNX_0VryuioZVBl9_xd6m2POKTxSTEBN4UH4caLa4GMM2DV3wQ46HBoKzUO_Te63eew3s--ejON2QPObfG4zA-cTcG97PPzb1MzXm0n5C1Ydrec</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1784607104</pqid></control><display><type>article</type><title>The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Nieuwenhuis, Wouter P. ; van Steenbergen, Hanna W. ; Stomp, Wouter ; Stijnen, Theo ; Huizinga, Tom W. J. ; Bloem, Johan L. ; van der Heijde, Désirée ; Reijnierse, Monique ; van der Helm‐van Mil, Annette H. M.</creator><creatorcontrib>Nieuwenhuis, Wouter P. ; van Steenbergen, Hanna W. ; Stomp, Wouter ; Stijnen, Theo ; Huizinga, Tom W. J. ; Bloem, Johan L. ; van der Heijde, Désirée ; Reijnierse, Monique ; van der Helm‐van Mil, Annette H. M.</creatorcontrib><description>Objective
In patients with rheumatoid arthritis (RA), bone marrow edema (BME) scores are associated with development of erosions. However, little is known about the course and outcome of BME at bone level. We undertook this study to determine the association of BME and synovitis with the development of erosions in the same bone longitudinally.
Methods
Using 1.5T magnetic resonance imaging at baseline and at 4‐ and 12‐month follow‐up, we studied 1,947 bones of the metacarpophalangeal, wrist, and metatarsophalangeal joints in 59 patients presenting with RA or undifferentiated arthritis. Scanning and scoring of BME, synovitis, and erosions were performed according to the Outcome Measures in Rheumatology Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system. We evaluated the relationship of the course of BME and synovitis with erosive progression at bone level during 1 year.
Results
Of the bones showing BME at baseline (n = 203), BME persisted in 56%, disappeared in 39%, and disappeared and then reappeared in 5%. Stratified analyses at baseline revealed that BME was associated with erosive progression both in the presence and in the absence of local synovitis, with odds ratios (ORs) of 7.5 (95% confidence interval [95% CI] 3.8–14.9) and 6.9 (95% CI 1.9–25.6), respectively. However, local synovitis was not associated with erosive progression in the presence or in the absence of BME (ORs of 2.0 [95% CI 0.6–7.0] and 1.9 [95% CI 0.8–4.1], respectively). In multivariable generalized estimating equation analyses, persistent BME was strongly associated with erosive progression (OR 60.5 [95% CI 16.8–218.1]) in contrast to persistent synovitis (OR 1.3 [95% CI 0.4–4.4]).
Conclusion
BME frequently persists during the first year. Persistent BME was strongly associated with erosive progression in the same bone, independently of local synovitis. No independent association was observed for persistent synovitis. These findings are relevant for comprehending the development of erosions in RA.</description><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.39550</identifier><identifier>PMID: 26681086</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Arthritis - diagnostic imaging ; Arthritis, Rheumatoid - diagnostic imaging ; Bone and Bones - diagnostic imaging ; Bone marrow ; Bone Marrow - diagnostic imaging ; Bone Marrow Diseases - diagnostic imaging ; Confidence intervals ; Disease Progression ; Edema ; Edema - diagnostic imaging ; Female ; Hand Joints - diagnostic imaging ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Metacarpophalangeal Joint - diagnostic imaging ; Metatarsophalangeal Joint - diagnostic imaging ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Rheumatism ; Rheumatoid arthritis ; Synovitis - diagnostic imaging ; Wrist Joint - diagnostic imaging</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2016-05, Vol.68 (5), p.1080-1088</ispartof><rights>2016, American College of Rheumatology</rights><rights>2016, American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4870-a6634dce0156ddd8d046c1ba8f71f2645399c01299158eaae15d49829499b9743</citedby><cites>FETCH-LOGICAL-c4870-a6634dce0156ddd8d046c1ba8f71f2645399c01299158eaae15d49829499b9743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.39550$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.39550$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26681086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nieuwenhuis, Wouter P.</creatorcontrib><creatorcontrib>van Steenbergen, Hanna W.</creatorcontrib><creatorcontrib>Stomp, Wouter</creatorcontrib><creatorcontrib>Stijnen, Theo</creatorcontrib><creatorcontrib>Huizinga, Tom W. J.</creatorcontrib><creatorcontrib>Bloem, Johan L.</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><creatorcontrib>Reijnierse, Monique</creatorcontrib><creatorcontrib>van der Helm‐van Mil, Annette H. M.</creatorcontrib><title>The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheumatol</addtitle><description>Objective
In patients with rheumatoid arthritis (RA), bone marrow edema (BME) scores are associated with development of erosions. However, little is known about the course and outcome of BME at bone level. We undertook this study to determine the association of BME and synovitis with the development of erosions in the same bone longitudinally.
Methods
Using 1.5T magnetic resonance imaging at baseline and at 4‐ and 12‐month follow‐up, we studied 1,947 bones of the metacarpophalangeal, wrist, and metatarsophalangeal joints in 59 patients presenting with RA or undifferentiated arthritis. Scanning and scoring of BME, synovitis, and erosions were performed according to the Outcome Measures in Rheumatology Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system. We evaluated the relationship of the course of BME and synovitis with erosive progression at bone level during 1 year.
Results
Of the bones showing BME at baseline (n = 203), BME persisted in 56%, disappeared in 39%, and disappeared and then reappeared in 5%. Stratified analyses at baseline revealed that BME was associated with erosive progression both in the presence and in the absence of local synovitis, with odds ratios (ORs) of 7.5 (95% confidence interval [95% CI] 3.8–14.9) and 6.9 (95% CI 1.9–25.6), respectively. However, local synovitis was not associated with erosive progression in the presence or in the absence of BME (ORs of 2.0 [95% CI 0.6–7.0] and 1.9 [95% CI 0.8–4.1], respectively). In multivariable generalized estimating equation analyses, persistent BME was strongly associated with erosive progression (OR 60.5 [95% CI 16.8–218.1]) in contrast to persistent synovitis (OR 1.3 [95% CI 0.4–4.4]).
Conclusion
BME frequently persists during the first year. Persistent BME was strongly associated with erosive progression in the same bone, independently of local synovitis. No independent association was observed for persistent synovitis. These findings are relevant for comprehending the development of erosions in RA.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis - diagnostic imaging</subject><subject>Arthritis, Rheumatoid - diagnostic imaging</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone marrow</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Bone Marrow Diseases - diagnostic imaging</subject><subject>Confidence intervals</subject><subject>Disease Progression</subject><subject>Edema</subject><subject>Edema - diagnostic imaging</subject><subject>Female</subject><subject>Hand Joints - diagnostic imaging</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Metacarpophalangeal Joint - diagnostic imaging</subject><subject>Metatarsophalangeal Joint - diagnostic imaging</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Rheumatism</subject><subject>Rheumatoid arthritis</subject><subject>Synovitis - diagnostic imaging</subject><subject>Wrist Joint - diagnostic imaging</subject><issn>2326-5191</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqFDEUhgdRbKm98AUk4I1ebHsyk2QS77bLthZWhHV7PWQnZ3ZTZpKaZCz7LL6saacVEcTcnMD5-Dj8f1G8pXBGAcpzHdJZpTiHF8VxWZVixkvgL5__VNGj4jTGW8hP1SCAvy6OSiEkBSmOi5-bPZKFH0NE4jty4R2SLzoEf0-WBgdNrCNLHfoDuXHGdh0GdMnqhIbMQ9oHm2wk2hmy3uM46OTtH4tPZE5W3u1sGo11us_mncNkW7LG6J12LZLrQe-s25FvmTkQnaYTVvgD-zfFq073EU-f5klxc7ncLD7PVl-vrhfz1axlsoaZFqJipkWgXBhjpAEmWrrVsqtpVwrGK6VaoKVSlEvUGik3TMlSMaW2qmbVSfFh8t4F_33EmJrBxhb7Xjv0Y2yohBwvZNX_0VryuioZVBl9_xd6m2POKTxSTEBN4UH4caLa4GMM2DV3wQ46HBoKzUO_Te63eew3s--ejON2QPObfG4zA-cTcG97PPzb1MzXm0n5C1Ydrec</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Nieuwenhuis, Wouter P.</creator><creator>van Steenbergen, Hanna W.</creator><creator>Stomp, Wouter</creator><creator>Stijnen, Theo</creator><creator>Huizinga, Tom W. J.</creator><creator>Bloem, Johan L.</creator><creator>van der Heijde, Désirée</creator><creator>Reijnierse, Monique</creator><creator>van der Helm‐van Mil, Annette H. M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201605</creationdate><title>The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level</title><author>Nieuwenhuis, Wouter P. ; van Steenbergen, Hanna W. ; Stomp, Wouter ; Stijnen, Theo ; Huizinga, Tom W. J. ; Bloem, Johan L. ; van der Heijde, Désirée ; Reijnierse, Monique ; van der Helm‐van Mil, Annette H. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4870-a6634dce0156ddd8d046c1ba8f71f2645399c01299158eaae15d49829499b9743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis - diagnostic imaging</topic><topic>Arthritis, Rheumatoid - diagnostic imaging</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone marrow</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Bone Marrow Diseases - diagnostic imaging</topic><topic>Confidence intervals</topic><topic>Disease Progression</topic><topic>Edema</topic><topic>Edema - diagnostic imaging</topic><topic>Female</topic><topic>Hand Joints - diagnostic imaging</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Metacarpophalangeal Joint - diagnostic imaging</topic><topic>Metatarsophalangeal Joint - diagnostic imaging</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Rheumatism</topic><topic>Rheumatoid arthritis</topic><topic>Synovitis - diagnostic imaging</topic><topic>Wrist Joint - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nieuwenhuis, Wouter P.</creatorcontrib><creatorcontrib>van Steenbergen, Hanna W.</creatorcontrib><creatorcontrib>Stomp, Wouter</creatorcontrib><creatorcontrib>Stijnen, Theo</creatorcontrib><creatorcontrib>Huizinga, Tom W. J.</creatorcontrib><creatorcontrib>Bloem, Johan L.</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><creatorcontrib>Reijnierse, Monique</creatorcontrib><creatorcontrib>van der Helm‐van Mil, Annette H. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nieuwenhuis, Wouter P.</au><au>van Steenbergen, Hanna W.</au><au>Stomp, Wouter</au><au>Stijnen, Theo</au><au>Huizinga, Tom W. J.</au><au>Bloem, Johan L.</au><au>van der Heijde, Désirée</au><au>Reijnierse, Monique</au><au>van der Helm‐van Mil, Annette H. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheumatol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>68</volume><issue>5</issue><spage>1080</spage><epage>1088</epage><pages>1080-1088</pages><issn>2326-5191</issn><eissn>2326-5205</eissn><abstract>Objective
In patients with rheumatoid arthritis (RA), bone marrow edema (BME) scores are associated with development of erosions. However, little is known about the course and outcome of BME at bone level. We undertook this study to determine the association of BME and synovitis with the development of erosions in the same bone longitudinally.
Methods
Using 1.5T magnetic resonance imaging at baseline and at 4‐ and 12‐month follow‐up, we studied 1,947 bones of the metacarpophalangeal, wrist, and metatarsophalangeal joints in 59 patients presenting with RA or undifferentiated arthritis. Scanning and scoring of BME, synovitis, and erosions were performed according to the Outcome Measures in Rheumatology Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system. We evaluated the relationship of the course of BME and synovitis with erosive progression at bone level during 1 year.
Results
Of the bones showing BME at baseline (n = 203), BME persisted in 56%, disappeared in 39%, and disappeared and then reappeared in 5%. Stratified analyses at baseline revealed that BME was associated with erosive progression both in the presence and in the absence of local synovitis, with odds ratios (ORs) of 7.5 (95% confidence interval [95% CI] 3.8–14.9) and 6.9 (95% CI 1.9–25.6), respectively. However, local synovitis was not associated with erosive progression in the presence or in the absence of BME (ORs of 2.0 [95% CI 0.6–7.0] and 1.9 [95% CI 0.8–4.1], respectively). In multivariable generalized estimating equation analyses, persistent BME was strongly associated with erosive progression (OR 60.5 [95% CI 16.8–218.1]) in contrast to persistent synovitis (OR 1.3 [95% CI 0.4–4.4]).
Conclusion
BME frequently persists during the first year. Persistent BME was strongly associated with erosive progression in the same bone, independently of local synovitis. No independent association was observed for persistent synovitis. These findings are relevant for comprehending the development of erosions in RA.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26681086</pmid><doi>10.1002/art.39550</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Arthritis - diagnostic imaging Arthritis, Rheumatoid - diagnostic imaging Bone and Bones - diagnostic imaging Bone marrow Bone Marrow - diagnostic imaging Bone Marrow Diseases - diagnostic imaging Confidence intervals Disease Progression Edema Edema - diagnostic imaging Female Hand Joints - diagnostic imaging Humans Longitudinal Studies Magnetic Resonance Imaging Male Metacarpophalangeal Joint - diagnostic imaging Metatarsophalangeal Joint - diagnostic imaging Middle Aged NMR Nuclear magnetic resonance Rheumatism Rheumatoid arthritis Synovitis - diagnostic imaging Wrist Joint - diagnostic imaging |
| title | The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level |
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