Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis<inline-graphic xlink:href="sbox.jpg"/>

The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart. The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of the pore, and geneti...

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Veröffentlicht in:	The Journal of biological chemistry 2015-12, Vol.291 (9), p.4356-4373
Hauptverfasser:	Warne, Justin, Pryce, Gareth, Hill, Julia M, Shi, Xiao, Lenneras, Felicia, Puentes, Fabiola, Kip, Maarten, Hilditch, Laura, Walker, Paul, Simone, Michela I, Chan, AWEdith, Towers, Greg J, Coker, Alun R, Duchen, Michael R, Szabadkai, Gyorgy, Baker, David, Selwood, David L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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