Liraglutide as a Potentially Useful Agent for Regulating Appetite in Diabetic Patients with Hypothalamic Hyperphagia and Obesity
Hypothalamic hyperphagia and obesity are characterized by a lack of satiety and an abnormally high appetite that is difficult to control. We herein report the cases of two patients with hypothalamic hyperphagia and obesity with MRI-detectable hypothalamic lesions. These patients suffered from diabet...
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| Veröffentlicht in: | Internal Medicine 2014, Vol.53(16), pp.1791-1795 |
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| container_title | Internal Medicine |
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| creator | Ando, Takao Haraguchi, Ai Matsunaga, Tomoe Natsuda, Shoko Yamasaki, Hironori Usa, Toshiro Kawakami, Atsushi |
| description | Hypothalamic hyperphagia and obesity are characterized by a lack of satiety and an abnormally high appetite that is difficult to control. We herein report the cases of two patients with hypothalamic hyperphagia and obesity with MRI-detectable hypothalamic lesions. These patients suffered from diabetes mellitus associated with an abnormal eating behavior and weight gain. Liraglutide was successfully used to treat their diabetes mellitus and suppress their abnormal appetites. Glucagon-like peptide-1 analogues, including liraglutide, are promising treatment options in patients with hypothalamic hyperphagia and obesity, as these agents enhance the hypothalamic input of the satiety signal, which is lacking in such patients. |
| doi_str_mv | 10.2169/internalmedicine.53.1646 |
| format | Article |
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We herein report the cases of two patients with hypothalamic hyperphagia and obesity with MRI-detectable hypothalamic lesions. These patients suffered from diabetes mellitus associated with an abnormal eating behavior and weight gain. Liraglutide was successfully used to treat their diabetes mellitus and suppress their abnormal appetites. Glucagon-like peptide-1 analogues, including liraglutide, are promising treatment options in patients with hypothalamic hyperphagia and obesity, as these agents enhance the hypothalamic input of the satiety signal, which is lacking in such patients.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.53.1646</identifier><identifier>PMID: 25130112</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Aged ; Appetite - drug effects ; Diabetes Mellitus, Type 2 - complications ; GLP-1 ; Glucagon-Like Peptide 1 - administration & dosage ; Glucagon-Like Peptide 1 - analogs & derivatives ; Humans ; hyperphagia ; Hyperphagia - complications ; Hyperphagia - drug therapy ; Hypoglycemic Agents - administration & dosage ; Hypothalamic Diseases - complications ; Hypothalamic Diseases - drug therapy ; Hypothalamo-Hypophyseal System - drug effects ; hypothalamus ; Liraglutide ; Male ; obesity ; Obesity - complications ; Obesity - prevention & control ; satiety ; Treatment Outcome</subject><ispartof>Internal Medicine, 2014, Vol.53(16), pp.1791-1795</ispartof><rights>2014 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-183b8c404fd25c1e03e5fac26dd6d724e84cedd8432ec69aa111392c6c8a6df33</citedby><cites>FETCH-LOGICAL-c604t-183b8c404fd25c1e03e5fac26dd6d724e84cedd8432ec69aa111392c6c8a6df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25130112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ando, Takao</creatorcontrib><creatorcontrib>Haraguchi, Ai</creatorcontrib><creatorcontrib>Matsunaga, Tomoe</creatorcontrib><creatorcontrib>Natsuda, Shoko</creatorcontrib><creatorcontrib>Yamasaki, Hironori</creatorcontrib><creatorcontrib>Usa, Toshiro</creatorcontrib><creatorcontrib>Kawakami, Atsushi</creatorcontrib><title>Liraglutide as a Potentially Useful Agent for Regulating Appetite in Diabetic Patients with Hypothalamic Hyperphagia and Obesity</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Hypothalamic hyperphagia and obesity are characterized by a lack of satiety and an abnormally high appetite that is difficult to control. We herein report the cases of two patients with hypothalamic hyperphagia and obesity with MRI-detectable hypothalamic lesions. These patients suffered from diabetes mellitus associated with an abnormal eating behavior and weight gain. Liraglutide was successfully used to treat their diabetes mellitus and suppress their abnormal appetites. Glucagon-like peptide-1 analogues, including liraglutide, are promising treatment options in patients with hypothalamic hyperphagia and obesity, as these agents enhance the hypothalamic input of the satiety signal, which is lacking in such patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Appetite - drug effects</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>GLP-1</subject><subject>Glucagon-Like Peptide 1 - administration & dosage</subject><subject>Glucagon-Like Peptide 1 - analogs & derivatives</subject><subject>Humans</subject><subject>hyperphagia</subject><subject>Hyperphagia - complications</subject><subject>Hyperphagia - drug therapy</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypothalamic Diseases - complications</subject><subject>Hypothalamic Diseases - drug therapy</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>hypothalamus</subject><subject>Liraglutide</subject><subject>Male</subject><subject>obesity</subject><subject>Obesity - complications</subject><subject>Obesity - prevention & control</subject><subject>satiety</subject><subject>Treatment Outcome</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LGzEMhk1p6abb_oXiYy-T-msczzFsP7YQyFK650GxNRMvzszU9lBy259eh6Q5FEovEtL7SAK9hFDOloLr5qMfMsYBwgGdt37AZS2XXCv9giy4VE21ErJ-SRas4aYSJdyQNyk9MSbNqhGvyY2ouWSciwV53vgIfZizd0ghUaAPY8YhewjhSB8TdnOg6750aDdG-h37OUD2Q0_X04TZZ6R-oJ887Eph6UPRCpvoL5_39P44jXkPAQ5FKgXGaQ-9BwqDo9sdJp-Pb8mrDkLCd5d8Sx6_fP5xd19ttl-_3a03ldVM5YobuTNWMdU5UVuOTGLdgRXaOe1WQqFRFp0zSgq0ugHgnMtGWG0NaNdJeUs-nPdOcfw5Y8rtwSeLIcCA45xablitGqO0-D9a10pp1mheUHNGbRxTiti1U_QHiMeWs_ZkVfu3VW0t25NVZfT95cq8K-J18I83BdiegaeUoccrALF8OuA_Np_i5cSVtHuILQ7yN_aNtEs</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Ando, Takao</creator><creator>Haraguchi, Ai</creator><creator>Matsunaga, Tomoe</creator><creator>Natsuda, Shoko</creator><creator>Yamasaki, Hironori</creator><creator>Usa, Toshiro</creator><creator>Kawakami, Atsushi</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140101</creationdate><title>Liraglutide as a Potentially Useful Agent for Regulating Appetite in Diabetic Patients with Hypothalamic Hyperphagia and Obesity</title><author>Ando, Takao ; Haraguchi, Ai ; Matsunaga, Tomoe ; Natsuda, Shoko ; Yamasaki, Hironori ; Usa, Toshiro ; Kawakami, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-183b8c404fd25c1e03e5fac26dd6d724e84cedd8432ec69aa111392c6c8a6df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Appetite - drug effects</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>GLP-1</topic><topic>Glucagon-Like Peptide 1 - administration & dosage</topic><topic>Glucagon-Like Peptide 1 - analogs & derivatives</topic><topic>Humans</topic><topic>hyperphagia</topic><topic>Hyperphagia - complications</topic><topic>Hyperphagia - drug therapy</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypothalamic Diseases - complications</topic><topic>Hypothalamic Diseases - drug therapy</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>hypothalamus</topic><topic>Liraglutide</topic><topic>Male</topic><topic>obesity</topic><topic>Obesity - complications</topic><topic>Obesity - prevention & control</topic><topic>satiety</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ando, Takao</creatorcontrib><creatorcontrib>Haraguchi, Ai</creatorcontrib><creatorcontrib>Matsunaga, Tomoe</creatorcontrib><creatorcontrib>Natsuda, Shoko</creatorcontrib><creatorcontrib>Yamasaki, Hironori</creatorcontrib><creatorcontrib>Usa, Toshiro</creatorcontrib><creatorcontrib>Kawakami, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ando, Takao</au><au>Haraguchi, Ai</au><au>Matsunaga, Tomoe</au><au>Natsuda, Shoko</au><au>Yamasaki, Hironori</au><au>Usa, Toshiro</au><au>Kawakami, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liraglutide as a Potentially Useful Agent for Regulating Appetite in Diabetic Patients with Hypothalamic Hyperphagia and Obesity</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>53</volume><issue>16</issue><spage>1791</spage><epage>1795</epage><pages>1791-1795</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Hypothalamic hyperphagia and obesity are characterized by a lack of satiety and an abnormally high appetite that is difficult to control. We herein report the cases of two patients with hypothalamic hyperphagia and obesity with MRI-detectable hypothalamic lesions. These patients suffered from diabetes mellitus associated with an abnormal eating behavior and weight gain. Liraglutide was successfully used to treat their diabetes mellitus and suppress their abnormal appetites. Glucagon-like peptide-1 analogues, including liraglutide, are promising treatment options in patients with hypothalamic hyperphagia and obesity, as these agents enhance the hypothalamic input of the satiety signal, which is lacking in such patients.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>25130112</pmid><doi>10.2169/internalmedicine.53.1646</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2014, Vol.53(16), pp.1791-1795 |
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| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adult Aged Appetite - drug effects Diabetes Mellitus, Type 2 - complications GLP-1 Glucagon-Like Peptide 1 - administration & dosage Glucagon-Like Peptide 1 - analogs & derivatives Humans hyperphagia Hyperphagia - complications Hyperphagia - drug therapy Hypoglycemic Agents - administration & dosage Hypothalamic Diseases - complications Hypothalamic Diseases - drug therapy Hypothalamo-Hypophyseal System - drug effects hypothalamus Liraglutide Male obesity Obesity - complications Obesity - prevention & control satiety Treatment Outcome |
| title | Liraglutide as a Potentially Useful Agent for Regulating Appetite in Diabetic Patients with Hypothalamic Hyperphagia and Obesity |
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