Acid-inducible proton influx currents in the plasma membrane of murine osteoclast-like cells

Acidification of the resorption pits, which is essential for dissolving bone, is produced by secretion of protons through vacuolar H + -ATPases in the plasma membrane of bone-resorbing cells, osteoclasts. Consequently, osteoclasts face highly acidic extracellular environments, where the pH gradient...

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Veröffentlicht in:	Pflügers Archiv 2016-05, Vol.468 (5), p.837-847
Hauptverfasser:	Kuno, Miyuki, Li, Guangshuai, Moriura, Yoshie, Hino, Yoshiko, Kawawaki, Junko, Sakai, Hiromu
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology Action Potentials Animals Biomedical and Life Sciences Biomedicine Calcium - pharmacology Cell Biology Cell Membrane - drug effects Cell Membrane - metabolism Cercopithecus aethiops Chlorides - pharmacology COS Cells Human Physiology Hydrogen-Ion Concentration Ion Channels Ion Channels - drug effects Ion Channels - metabolism Mice Molecular Medicine Neurosciences Osteoclasts - metabolism Protons Receptors Receptors and Transporters Zinc Compounds - pharmacology
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