Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage–Randomized, Placebo-Controlled, Double-Blind, Crossover Study
Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid ex...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2016/05/01, Vol.39(5), pp.699-704 |
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| creator | Ashigai, Hiroshi Taniguchi, Yoshimasa Suzuki, Mihoko Ikeshima, Emiko Kanaya, Tomoka Zembutsu, Kanako Tomita, Shimpei Miyake, Mika Fukuhara, Ikuo |
| description | Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51±1.73 to 6.87±1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion. |
| doi_str_mv | 10.1248/bpb.b15-00662 |
| format | Article |
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Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51±1.73 to 6.87±1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b15-00662</identifier><identifier>PMID: 26887502</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Adult ; black tea polyphenol ; clinical study ; Cross-Over Studies ; Dietary Fats - pharmacokinetics ; Double-Blind Method ; fecal lipid ; Feces - chemistry ; Female ; Humans ; Intestinal Absorption - drug effects ; Lipid Metabolism - drug effects ; Male ; Middle Aged ; Polyphenols - pharmacology ; Tea - chemistry ; Young Adult</subject><ispartof>Biological and Pharmaceutical Bulletin, 2016/05/01, Vol.39(5), pp.699-704</ispartof><rights>2016 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-d7a077497055fccd774e386258556200ed5a5dc14010c8e60fd2f3cd96a432393</citedby><cites>FETCH-LOGICAL-c735t-d7a077497055fccd774e386258556200ed5a5dc14010c8e60fd2f3cd96a432393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26887502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashigai, Hiroshi</creatorcontrib><creatorcontrib>Taniguchi, Yoshimasa</creatorcontrib><creatorcontrib>Suzuki, Mihoko</creatorcontrib><creatorcontrib>Ikeshima, Emiko</creatorcontrib><creatorcontrib>Kanaya, Tomoka</creatorcontrib><creatorcontrib>Zembutsu, Kanako</creatorcontrib><creatorcontrib>Tomita, Shimpei</creatorcontrib><creatorcontrib>Miyake, Mika</creatorcontrib><creatorcontrib>Fukuhara, Ikuo</creatorcontrib><creatorcontrib>dNew Drug Research Center</creatorcontrib><creatorcontrib>eFukuhara Clinic</creatorcontrib><creatorcontrib>aResearch Laboratories for Health Science & Food Technologies</creatorcontrib><creatorcontrib>bResearch Laboratories for Key Technologies</creatorcontrib><creatorcontrib>Ltd</creatorcontrib><creatorcontrib>cResearch Laboratories for Product Development</creatorcontrib><creatorcontrib>Kirin Beverage Co</creatorcontrib><creatorcontrib>Inc</creatorcontrib><creatorcontrib>Kirin Co</creatorcontrib><title>Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage–Randomized, Placebo-Controlled, Double-Blind, Crossover Study</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51±1.73 to 6.87±1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.</description><subject>Adult</subject><subject>black tea polyphenol</subject><subject>clinical study</subject><subject>Cross-Over Studies</subject><subject>Dietary Fats - pharmacokinetics</subject><subject>Double-Blind Method</subject><subject>fecal lipid</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Absorption - drug effects</subject><subject>Lipid Metabolism - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polyphenols - pharmacology</subject><subject>Tea - chemistry</subject><subject>Young Adult</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstu1DAUhiMEoqWwZIsssWFBii_xJUtmaAvSSFRQ1pZjn7QePHHqJIhhxTsgXpAnwZkpg8SKjS_H3_nPsX8XxVOCTwmt1Kumb04bwkuMhaD3imPCKllySvj94hjXRJWCcHVUPBqGNcZYYsoeFkdUKCU5psfFz3OwJqCV771DZ19tgtHHDpl2hISWsRumTb-LxBYZtAjGfkZXYNBlDNv-BroYZmo0vvPdNVrAF0jmGn59__HBdC5u_DdwL9FlToMmljOZYghz7E2cmgDlIvgu75YpDkPMyejjOLnt4-JBa8IAT-7mk-LT-dnV8m25en_xbvl6VVrJ-Fg6abCUVS0x5621Lq-BKUG54lxQjMFxw50lFSbYKhC4dbRl1tXCVIyymp0UL_a6fYq3Ewyj3vjBQgimgzgNmijMs7yg_4FKJStJKqEy-vwfdB2n1OWL7ChMlWIzVe4pO989Qav75DcmbTXBerZWZ2t1tlbvrM38szvVqdmAO9B_vMzAxR7Ipz6bGrv8tvC3th1k42OImmIisiir8awtNRZ1rfPXqKjgNavm1pZ7pfUwZjcPpUwavQ2wa4zVms_DocHDqb0xSUPHfgOs_c41</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Ashigai, Hiroshi</creator><creator>Taniguchi, Yoshimasa</creator><creator>Suzuki, Mihoko</creator><creator>Ikeshima, Emiko</creator><creator>Kanaya, Tomoka</creator><creator>Zembutsu, Kanako</creator><creator>Tomita, Shimpei</creator><creator>Miyake, Mika</creator><creator>Fukuhara, Ikuo</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20160501</creationdate><title>Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage–Randomized, Placebo-Controlled, Double-Blind, Crossover Study</title><author>Ashigai, Hiroshi ; 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Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51±1.73 to 6.87±1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>26887502</pmid><doi>10.1248/bpb.b15-00662</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological and Pharmaceutical Bulletin, 2016/05/01, Vol.39(5), pp.699-704 |
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| subjects | Adult black tea polyphenol clinical study Cross-Over Studies Dietary Fats - pharmacokinetics Double-Blind Method fecal lipid Feces - chemistry Female Humans Intestinal Absorption - drug effects Lipid Metabolism - drug effects Male Middle Aged Polyphenols - pharmacology Tea - chemistry Young Adult |
| title | Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage–Randomized, Placebo-Controlled, Double-Blind, Crossover Study |
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