Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling

Gastrodia elata Blume is a highly valuable traditional Chinese medicine used in the treatment of depression. However, compounds with antidepressant effects in water extracts of G. elata Bl. (WGE) have not been identified. The aims of this study were to determine the major antidepressant compound in...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-04, Vol.182, p.190-199
Hauptverfasser:	Chen, Wei-Cheng, Lai, Yi-Syuan, Lin, Shih-Hang, Lu, Kuan-Hung, Lin, Yu-En, Panyod, Suraphan, Ho, Chi-Tang, Sheen, Lee-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism 4-hydroxybenzyl alcohol Animals Anti-depressant Antidepressive Agents - pharmacology Behavior, Animal - drug effects Benzyl Alcohols - pharmacology Brain - drug effects Brain - metabolism Cell Line, Tumor Cytoskeleton - drug effects Dopamine - metabolism Exploratory Behavior - drug effects Forced swimming test Gastrodia Gastrodia elata Gastrodia elata Blume Gastrodin Glucosides - pharmacology Homovanillic Acid - metabolism Humans Hydroxyindoleacetic Acid - metabolism Male Neurons - drug effects Plant Extracts - pharmacology Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1A - metabolism Serotonin - metabolism
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