Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure
Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 wk old). Fur...
Gespeichert in:
Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2016-04, Vol.310 (7), p.R612-R618 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | R618 |
---|---|
container_issue | 7 |
container_start_page | R612 |
container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
container_volume | 310 |
creator | Pinto, Tomás O C Teixeira Lataro, Renata M Castania, Jaci A Durand, Marina T Silva, Carlos A A Patel, Kaushik P Fazan, Jr, Rubens Salgado, Helio C |
description | Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 wk old). Furthermore, the role of parasympathetic and sympathetic nervous system in mediating the cardiovascular responses to baroreflex activation was evaluated by selective β1-adrenergic and muscarinic receptor antagonists. CHF was induced by myocardial infarction. After 6 wk, the subjects were implanted with electrodes for ADN stimulation. Twenty-four hours later, electrical stimulation of the ADN was applied for 20 s using five different frequencies (5, 15, 30, 60, and 90 Hz), while the arterial pressure was recorded by a catheter implanted into the femoral artery. Electrical stimulation of the ADN elicited progressive and similar hypotensive and bradycardic responses in control (n = 12) and CHF (n = 11) rats, while the hypotensive response was not affected by methylatropine. Nevertheless, the reflex bradycardia was attenuated by methylatropine in control, but not in CHF rats. Atenolol did not affect the hypotensive or bradycardic response in either group. The ADN function was examined under anesthesia through electroneurographic recordings. The arterial pressure-ADN activity relationship was attenuated in CHF rats. In conclusion, despite the attenuation of baroreceptor function in CHF rats, the electrical stimulation of the ADN elicited a stimulus-dependent hypotension and bradycardia of similar magnitude as observed in control rats. Therefore, electrical activation of the aortic baroreflex overcomes both the attenuation of parasympathetic function and the sympathetic overdrive. |
doi_str_mv | 10.1152/ajpregu.00392.2015 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1805497570</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1805497570</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-fa250a80b3a9c1abaa51ec3df304bd3f81667dfa9bb35d3d0e77e84fe87894bd3</originalsourceid><addsrcrecordid>eNqFkc1u1DAURi0EotPCC7BAltiwyXAdx7GzRFX5kSqxgXV041wzHiXxYDsVfYa-NJ7OgAQbVl74fJ9972HslYCtEKp-h_tDpO_rFkB29bYGoZ6wTbmoK9F08JRtQLayaoXoLthlSnsAaGQjn7OLujWNVKbesIebiWyO3uLEU_bzOmH2YeHB8bwjjiFmb_lI5aWUQuQLxTvifuE2LMn6sCYeMSce7ijaMFM6xXKmZf2racAYIrmJfj6mdzEspXhHGDN36Kc10gv2zOGU6OX5vGLfPtx8vf5U3X75-Pn6_W1ly_dz5bBWgAYGiZ0VOCAqQVaOTkIzjNIZ0bZ6dNgNg1SjHIG0JtM4Mtp0R-KKvT31HmL4sVLK_eyTpWnChcpAvTCgmk4rDf9HtdadUbqTBX3zD7oPa1zKIIUyQinQoAtVnygbQ0plIf0h-hnjfS-gP1rtz1b7R6v90WoJvT5Xr8NM45_Ib43yF7qioo8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781550707</pqid></control><display><type>article</type><title>Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure</title><source>MEDLINE</source><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Pinto, Tomás O C Teixeira ; Lataro, Renata M ; Castania, Jaci A ; Durand, Marina T ; Silva, Carlos A A ; Patel, Kaushik P ; Fazan, Jr, Rubens ; Salgado, Helio C</creator><creatorcontrib>Pinto, Tomás O C Teixeira ; Lataro, Renata M ; Castania, Jaci A ; Durand, Marina T ; Silva, Carlos A A ; Patel, Kaushik P ; Fazan, Jr, Rubens ; Salgado, Helio C</creatorcontrib><description>Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 wk old). Furthermore, the role of parasympathetic and sympathetic nervous system in mediating the cardiovascular responses to baroreflex activation was evaluated by selective β1-adrenergic and muscarinic receptor antagonists. CHF was induced by myocardial infarction. After 6 wk, the subjects were implanted with electrodes for ADN stimulation. Twenty-four hours later, electrical stimulation of the ADN was applied for 20 s using five different frequencies (5, 15, 30, 60, and 90 Hz), while the arterial pressure was recorded by a catheter implanted into the femoral artery. Electrical stimulation of the ADN elicited progressive and similar hypotensive and bradycardic responses in control (n = 12) and CHF (n = 11) rats, while the hypotensive response was not affected by methylatropine. Nevertheless, the reflex bradycardia was attenuated by methylatropine in control, but not in CHF rats. Atenolol did not affect the hypotensive or bradycardic response in either group. The ADN function was examined under anesthesia through electroneurographic recordings. The arterial pressure-ADN activity relationship was attenuated in CHF rats. In conclusion, despite the attenuation of baroreceptor function in CHF rats, the electrical stimulation of the ADN elicited a stimulus-dependent hypotension and bradycardia of similar magnitude as observed in control rats. Therefore, electrical activation of the aortic baroreflex overcomes both the attenuation of parasympathetic function and the sympathetic overdrive.</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00392.2015</identifier><identifier>PMID: 26843582</identifier><identifier>CODEN: AJPRDO</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Aorta - innervation ; Baroreflex ; Blood Pressure ; Coronary vessels ; Electric Stimulation Therapy - methods ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart Rate ; Male ; Rats ; Rats, Wistar ; Rodents ; Transcutaneous Electric Nerve Stimulation - methods ; Treatment Outcome</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2016-04, Vol.310 (7), p.R612-R618</ispartof><rights>Copyright © 2016 the American Physiological Society.</rights><rights>Copyright American Physiological Society Apr 1, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-fa250a80b3a9c1abaa51ec3df304bd3f81667dfa9bb35d3d0e77e84fe87894bd3</citedby><cites>FETCH-LOGICAL-c434t-fa250a80b3a9c1abaa51ec3df304bd3f81667dfa9bb35d3d0e77e84fe87894bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26843582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto, Tomás O C Teixeira</creatorcontrib><creatorcontrib>Lataro, Renata M</creatorcontrib><creatorcontrib>Castania, Jaci A</creatorcontrib><creatorcontrib>Durand, Marina T</creatorcontrib><creatorcontrib>Silva, Carlos A A</creatorcontrib><creatorcontrib>Patel, Kaushik P</creatorcontrib><creatorcontrib>Fazan, Jr, Rubens</creatorcontrib><creatorcontrib>Salgado, Helio C</creatorcontrib><title>Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 wk old). Furthermore, the role of parasympathetic and sympathetic nervous system in mediating the cardiovascular responses to baroreflex activation was evaluated by selective β1-adrenergic and muscarinic receptor antagonists. CHF was induced by myocardial infarction. After 6 wk, the subjects were implanted with electrodes for ADN stimulation. Twenty-four hours later, electrical stimulation of the ADN was applied for 20 s using five different frequencies (5, 15, 30, 60, and 90 Hz), while the arterial pressure was recorded by a catheter implanted into the femoral artery. Electrical stimulation of the ADN elicited progressive and similar hypotensive and bradycardic responses in control (n = 12) and CHF (n = 11) rats, while the hypotensive response was not affected by methylatropine. Nevertheless, the reflex bradycardia was attenuated by methylatropine in control, but not in CHF rats. Atenolol did not affect the hypotensive or bradycardic response in either group. The ADN function was examined under anesthesia through electroneurographic recordings. The arterial pressure-ADN activity relationship was attenuated in CHF rats. In conclusion, despite the attenuation of baroreceptor function in CHF rats, the electrical stimulation of the ADN elicited a stimulus-dependent hypotension and bradycardia of similar magnitude as observed in control rats. Therefore, electrical activation of the aortic baroreflex overcomes both the attenuation of parasympathetic function and the sympathetic overdrive.</description><subject>Animals</subject><subject>Aorta - innervation</subject><subject>Baroreflex</subject><subject>Blood Pressure</subject><subject>Coronary vessels</subject><subject>Electric Stimulation Therapy - methods</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart Rate</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Transcutaneous Electric Nerve Stimulation - methods</subject><subject>Treatment Outcome</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EotPCC7BAltiwyXAdx7GzRFX5kSqxgXV041wzHiXxYDsVfYa-NJ7OgAQbVl74fJ9972HslYCtEKp-h_tDpO_rFkB29bYGoZ6wTbmoK9F08JRtQLayaoXoLthlSnsAaGQjn7OLujWNVKbesIebiWyO3uLEU_bzOmH2YeHB8bwjjiFmb_lI5aWUQuQLxTvifuE2LMn6sCYeMSce7ijaMFM6xXKmZf2racAYIrmJfj6mdzEspXhHGDN36Kc10gv2zOGU6OX5vGLfPtx8vf5U3X75-Pn6_W1ly_dz5bBWgAYGiZ0VOCAqQVaOTkIzjNIZ0bZ6dNgNg1SjHIG0JtM4Mtp0R-KKvT31HmL4sVLK_eyTpWnChcpAvTCgmk4rDf9HtdadUbqTBX3zD7oPa1zKIIUyQinQoAtVnygbQ0plIf0h-hnjfS-gP1rtz1b7R6v90WoJvT5Xr8NM45_Ib43yF7qioo8</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Pinto, Tomás O C Teixeira</creator><creator>Lataro, Renata M</creator><creator>Castania, Jaci A</creator><creator>Durand, Marina T</creator><creator>Silva, Carlos A A</creator><creator>Patel, Kaushik P</creator><creator>Fazan, Jr, Rubens</creator><creator>Salgado, Helio C</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure</title><author>Pinto, Tomás O C Teixeira ; Lataro, Renata M ; Castania, Jaci A ; Durand, Marina T ; Silva, Carlos A A ; Patel, Kaushik P ; Fazan, Jr, Rubens ; Salgado, Helio C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-fa250a80b3a9c1abaa51ec3df304bd3f81667dfa9bb35d3d0e77e84fe87894bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Aorta - innervation</topic><topic>Baroreflex</topic><topic>Blood Pressure</topic><topic>Coronary vessels</topic><topic>Electric Stimulation Therapy - methods</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart Rate</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Transcutaneous Electric Nerve Stimulation - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinto, Tomás O C Teixeira</creatorcontrib><creatorcontrib>Lataro, Renata M</creatorcontrib><creatorcontrib>Castania, Jaci A</creatorcontrib><creatorcontrib>Durand, Marina T</creatorcontrib><creatorcontrib>Silva, Carlos A A</creatorcontrib><creatorcontrib>Patel, Kaushik P</creatorcontrib><creatorcontrib>Fazan, Jr, Rubens</creatorcontrib><creatorcontrib>Salgado, Helio C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinto, Tomás O C Teixeira</au><au>Lataro, Renata M</au><au>Castania, Jaci A</au><au>Durand, Marina T</au><au>Silva, Carlos A A</au><au>Patel, Kaushik P</au><au>Fazan, Jr, Rubens</au><au>Salgado, Helio C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>310</volume><issue>7</issue><spage>R612</spage><epage>R618</epage><pages>R612-R618</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><coden>AJPRDO</coden><abstract>Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 wk old). Furthermore, the role of parasympathetic and sympathetic nervous system in mediating the cardiovascular responses to baroreflex activation was evaluated by selective β1-adrenergic and muscarinic receptor antagonists. CHF was induced by myocardial infarction. After 6 wk, the subjects were implanted with electrodes for ADN stimulation. Twenty-four hours later, electrical stimulation of the ADN was applied for 20 s using five different frequencies (5, 15, 30, 60, and 90 Hz), while the arterial pressure was recorded by a catheter implanted into the femoral artery. Electrical stimulation of the ADN elicited progressive and similar hypotensive and bradycardic responses in control (n = 12) and CHF (n = 11) rats, while the hypotensive response was not affected by methylatropine. Nevertheless, the reflex bradycardia was attenuated by methylatropine in control, but not in CHF rats. Atenolol did not affect the hypotensive or bradycardic response in either group. The ADN function was examined under anesthesia through electroneurographic recordings. The arterial pressure-ADN activity relationship was attenuated in CHF rats. In conclusion, despite the attenuation of baroreceptor function in CHF rats, the electrical stimulation of the ADN elicited a stimulus-dependent hypotension and bradycardia of similar magnitude as observed in control rats. Therefore, electrical activation of the aortic baroreflex overcomes both the attenuation of parasympathetic function and the sympathetic overdrive.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>26843582</pmid><doi>10.1152/ajpregu.00392.2015</doi></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0363-6119 |
ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2016-04, Vol.310 (7), p.R612-R618 |
issn | 0363-6119 1522-1490 |
language | eng |
recordid | cdi_proquest_miscellaneous_1805497570 |
source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Animals Aorta - innervation Baroreflex Blood Pressure Coronary vessels Electric Stimulation Therapy - methods Heart failure Heart Failure - diagnosis Heart Failure - physiopathology Heart Failure - therapy Heart Rate Male Rats Rats, Wistar Rodents Transcutaneous Electric Nerve Stimulation - methods Treatment Outcome |
title | Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T15%3A01%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electrical%20stimulation%20of%20the%20aortic%20depressor%20nerve%20in%20conscious%20rats%20overcomes%20the%20attenuation%20of%20the%20baroreflex%20in%20chronic%20heart%20failure&rft.jtitle=American%20journal%20of%20physiology.%20Regulatory,%20integrative%20and%20comparative%20physiology&rft.au=Pinto,%20Tom%C3%A1s%20O%20C%20Teixeira&rft.date=2016-04-01&rft.volume=310&rft.issue=7&rft.spage=R612&rft.epage=R618&rft.pages=R612-R618&rft.issn=0363-6119&rft.eissn=1522-1490&rft.coden=AJPRDO&rft_id=info:doi/10.1152/ajpregu.00392.2015&rft_dat=%3Cproquest_cross%3E1805497570%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781550707&rft_id=info:pmid/26843582&rfr_iscdi=true |