Safety and Efficacy of Intravenous Ultra-high Dose Methylcobalamin Treatment for Peripheral Neuropathy: A Phase I/II Open Label Clinical Trial

Objective No clinically effective treatment for promoting peripheral axonal regeneration has yet been established. Several experimental studies in vitro and in vivo have shown that a high dose of methylcobalamin (MeCbl), an analogue of vitamin B12, promotes axonal growth in peripheral nerve injury....

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Veröffentlicht in:	Internal Medicine 2014, Vol.53(17), pp.1927-1931
Hauptverfasser:	Shibuya, Kazumoto, Misawa, Sonoko, Nasu, Saiko, Sekiguchi, Yukari, Beppu, Minako, Iwai, Yuta, Mitsuma, Satsuki, Isose, Sagiri, Arimura, Kimiyoshi, Kaji, Ryuji, Kuwabara, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged axonal regeneration Axons - drug effects Axons - pathology Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans Infusions, Intravenous Male methylcobalamin Middle Aged Muscle, Skeletal - innervation Nerve Regeneration - drug effects Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - pathology peripheral neuropathy Time Factors Treatment Outcome Vitamin B 12 - administration & dosage Vitamin B 12 - analogs & derivatives
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