MiR-221 and miR-26b Regulate Chemotactic Migration of MSCs Toward HGF Through Activation of Akt and FAK

ABSTRACT The chemotactic migration of mesenchymal stem cells (MSCs) is fundamental for their use in cell‐based therapies, but little is known about the molecular mechanisms that regulate their directed migration. MicroRNAs (miRNAs) participate in the regulation of a large variety of cellular process...

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Veröffentlicht in:	Journal of cellular biochemistry 2016-06, Vol.117 (6), p.1370-1383
Hauptverfasser:	Zhu, Aisi, Kang, Naixin, He, Lihong, Li, Xianyang, Xu, Xiaojing, Zhang, Huanxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Cell migration Cell Movement - drug effects Chemotactic response Chemotaxis Chemotaxis - drug effects Chromosomes Focal adhesion kinase focal adhesion kinase (FAK) Focal Adhesion Kinase 1 - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Growth factors Hepatocyte growth factor hepatocyte growth factor (HGF) Hepatocyte Growth Factor - pharmacology Homology Kinases Mesenchymal stem cells mesenchymal stem cells (MSCs) Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchyme MicroRNAs MicroRNAs - genetics migration miR-221 and miR-26b miRNA Molecular modelling mRNA Phosphorylation Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN protein Rats Ribonucleic acid RNA Signal Transduction Stem cells Target recognition Tensin
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