Identification of drug resistance mutations in HIV from constraints on natural evolution

Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretro...

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Veröffentlicht in:	Physical review. E 2016-02, Vol.93 (2), p.022412-022412, Article 022412
Hauptverfasser:	Butler, Thomas C, Barton, John P, Kardar, Mehran, Chakraborty, Arup K
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Interactions Drug Resistance, Viral - genetics Evolution, Molecular HIV - drug effects HIV - enzymology HIV - genetics HIV Protease - genetics HIV Protease Inhibitors - pharmacology Humans Mutation
Online-Zugang:	Volltext
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