Identification of drug resistance mutations in HIV from constraints on natural evolution
Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretro...
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| Veröffentlicht in: | Physical review. E 2016-02, Vol.93 (2), p.022412-022412, Article 022412 |
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| container_end_page | 022412 |
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| container_issue | 2 |
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| container_title | Physical review. E |
| container_volume | 93 |
| creator | Butler, Thomas C Barton, John P Kardar, Mehran Chakraborty, Arup K |
| description | Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretroviral drugs, can be used to identify clinically significant sites of resistance mutations. Successful predictions of the resistance sites indicate progress in the development of successful models of real viral evolution at the single residue level and suggest that our approach may be applied to help design new therapies that are less prone to failure even where resistance data are not yet available. |
| doi_str_mv | 10.1103/PhysRevE.93.022412 |
| format | Article |
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| ispartof | Physical review. E, 2016-02, Vol.93 (2), p.022412-022412, Article 022412 |
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| language | eng |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Drug Interactions Drug Resistance, Viral - genetics Evolution, Molecular HIV - drug effects HIV - enzymology HIV - genetics HIV Protease - genetics HIV Protease Inhibitors - pharmacology Humans Mutation |
| title | Identification of drug resistance mutations in HIV from constraints on natural evolution |
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