The Role of the Th2 CC Chemokine Ligand CCL17 in Pulmonary Fibrosis

Increasing evidence suggests that the development of pulmonary fibrosis is a Th2-mediated process. We hypothesized that the CC chemokines that are associated with a Th2 profile (CCL17 and CCL22) have an important role in the development of pulmonary fibrosis. We measured CCL17 and CCL22 during the p...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-10, Vol.173 (7), p.4692-4698
Hauptverfasser:	Belperio, John A, Dy, Maria, Murray, Lynne, Burdick, Marie D, Xue, Ying Y, Strieter, Robert M, Keane, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - administration & dosage Bleomycin - pharmacology Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cell Division - immunology Cell Line Cell Movement - immunology Chemokine CCL17 Chemokine CCL22 Chemokines, CC - antagonists & inhibitors Chemokines, CC - biosynthesis Chemokines, CC - immunology Chemokines, CC - metabolism Chemokines, CC - physiology Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Female Fibroblasts - immunology Fibroblasts - pathology Humans Immunization, Passive Leukocyte Count Ligands Lung - drug effects Lung - immunology Lung - metabolism Lung - pathology Macrophages - metabolism Macrophages - pathology Mice Mice, Inbred CBA Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - immunology Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Receptors, CCR4 Receptors, Chemokine - biosynthesis Th2 Cells - immunology Th2 Cells - metabolism
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