Fetal-maternal complications and their association with gestational thrombocytopenia
Thrombocytopenia is defined as a platelet count of < 150 × 10⁹/L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate th...
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| Veröffentlicht in: | Ginekologia polska 2016-01, Vol.87 (6), p.454-459 |
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| creator | Elveđi-Gašparović, Vesna Beljan, Petrana Gverić-Ahmetašević, Snježana Schuster, Snježana Škrablin, Snježana |
| description | Thrombocytopenia is defined as a platelet count of < 150 × 10⁹/L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate the incidence of perinatal complications in pregnancies complicated with gestational thrombocytopenia and to determine if the severity of maternal gestational thrombocytopenia implicates unfavorable perinatal outcome.
Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50-100 × 10⁹/L - classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 10⁹/L - classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared.
Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01).
Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy. |
| doi_str_mv | 10.5603/GP.2016.0025 |
| format | Article |
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Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50-100 × 10⁹/L - classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 10⁹/L - classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared.
Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01).
Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy.</description><identifier>ISSN: 0017-0011</identifier><identifier>EISSN: 2543-6767</identifier><identifier>DOI: 10.5603/GP.2016.0025</identifier><identifier>PMID: 27418224</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adult ; Croatia - epidemiology ; Female ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Platelet Count - methods ; Pregnancy ; Pregnancy Complications, Hematologic - diagnosis ; Pregnancy Complications, Hematologic - epidemiology ; Risk Factors ; Severity of Illness Index ; Thrombocytopenia ; Thrombocytopenia - diagnosis ; Thrombocytopenia - epidemiology ; Thrombocytopenia - etiology ; Thrombocytopenia, Neonatal Alloimmune - diagnosis ; Thrombocytopenia, Neonatal Alloimmune - epidemiology ; Thrombocytopenia, Neonatal Alloimmune - etiology</subject><ispartof>Ginekologia polska, 2016-01, Vol.87 (6), p.454-459</ispartof><rights>2016. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-4195bb0aa7480eff668e27cec8a966415650fa15fd9311e066b4da3b9b33cf123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27418224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elveđi-Gašparović, Vesna</creatorcontrib><creatorcontrib>Beljan, Petrana</creatorcontrib><creatorcontrib>Gverić-Ahmetašević, Snježana</creatorcontrib><creatorcontrib>Schuster, Snježana</creatorcontrib><creatorcontrib>Škrablin, Snježana</creatorcontrib><title>Fetal-maternal complications and their association with gestational thrombocytopenia</title><title>Ginekologia polska</title><addtitle>Ginekol Pol</addtitle><description>Thrombocytopenia is defined as a platelet count of < 150 × 10⁹/L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate the incidence of perinatal complications in pregnancies complicated with gestational thrombocytopenia and to determine if the severity of maternal gestational thrombocytopenia implicates unfavorable perinatal outcome.
Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50-100 × 10⁹/L - classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 10⁹/L - classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared.
Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01).
Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy.</description><subject>Adult</subject><subject>Croatia - epidemiology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Platelet Count - methods</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic - diagnosis</subject><subject>Pregnancy Complications, Hematologic - epidemiology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - diagnosis</subject><subject>Thrombocytopenia - epidemiology</subject><subject>Thrombocytopenia - etiology</subject><subject>Thrombocytopenia, Neonatal Alloimmune - diagnosis</subject><subject>Thrombocytopenia, Neonatal Alloimmune - epidemiology</subject><subject>Thrombocytopenia, Neonatal Alloimmune - etiology</subject><issn>0017-0011</issn><issn>2543-6767</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkD1PwzAQhi0EolXpxowisTCQ4u8kI6poQapEhzJbjuNQV0lcbEeo_x6nLQzccKc7Pffq7gXgFsEZ45A8LdczDBGfQYjZBRhjRknKM55dgjGEKEtjQiMw9X4HY3Cc4aK4BiOcUZRjTMdgs9BBNmkrg3adbBJl231jlAzGdj6RXZWErTYukd5bZY7j5NuEbfKpfTi2cSlsnW1Lqw7B7nVn5A24qmXj9fRcJ-Bj8bKZv6ar9-Xb_HmVKsKykFJUsLKEUmY0h7quOc81zpRWuSw4p4hxBmuJWF0VBCENOS9pJUlZlISoGmEyAQ8n3b2zX308SLTGK900stO29wLlkOacFRhF9P4furP98LEXmHIaCQjzSD2eKOWs907XYu9MK91BICgGw8VyLQbDxWB4xO_Oon3Z6uoP_rWX_AAxyHrj</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Elveđi-Gašparović, Vesna</creator><creator>Beljan, Petrana</creator><creator>Gverić-Ahmetašević, Snježana</creator><creator>Schuster, Snježana</creator><creator>Škrablin, Snježana</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Fetal-maternal complications and their association with gestational thrombocytopenia</title><author>Elveđi-Gašparović, Vesna ; Beljan, Petrana ; Gverić-Ahmetašević, Snježana ; Schuster, Snježana ; Škrablin, Snježana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-4195bb0aa7480eff668e27cec8a966415650fa15fd9311e066b4da3b9b33cf123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Croatia - epidemiology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Platelet Count - methods</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic - diagnosis</topic><topic>Pregnancy Complications, Hematologic - epidemiology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - diagnosis</topic><topic>Thrombocytopenia - epidemiology</topic><topic>Thrombocytopenia - etiology</topic><topic>Thrombocytopenia, Neonatal Alloimmune - diagnosis</topic><topic>Thrombocytopenia, Neonatal Alloimmune - epidemiology</topic><topic>Thrombocytopenia, Neonatal Alloimmune - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elveđi-Gašparović, Vesna</creatorcontrib><creatorcontrib>Beljan, Petrana</creatorcontrib><creatorcontrib>Gverić-Ahmetašević, Snježana</creatorcontrib><creatorcontrib>Schuster, Snježana</creatorcontrib><creatorcontrib>Škrablin, Snježana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Ginekologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elveđi-Gašparović, Vesna</au><au>Beljan, Petrana</au><au>Gverić-Ahmetašević, Snježana</au><au>Schuster, Snježana</au><au>Škrablin, Snježana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal-maternal complications and their association with gestational thrombocytopenia</atitle><jtitle>Ginekologia polska</jtitle><addtitle>Ginekol Pol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>87</volume><issue>6</issue><spage>454</spage><epage>459</epage><pages>454-459</pages><issn>0017-0011</issn><eissn>2543-6767</eissn><abstract>Thrombocytopenia is defined as a platelet count of < 150 × 10⁹/L. It is a common hematologic abnormality during pregnancy. Evaluation and treatment of gestational thrombocytopenia can be both, expensive and invasive, and may result in an adverse outcome. The aim of our study was to investigate the incidence of perinatal complications in pregnancies complicated with gestational thrombocytopenia and to determine if the severity of maternal gestational thrombocytopenia implicates unfavorable perinatal outcome.
Over a period of three years, we identified 50 patients with gestational thrombocytopenia: 38 with platelet count between 50-100 × 10⁹/L - classified as moderate thrombocytopenia, and 12 with platelet count of < 50 × 10⁹/L - classified as severe thrombocytopenia. Fifty women with normal platelet count constituted the control group. Maternal complications and neonatal outcomes were compared.
Neonatal thrombocytopenia occurred more often in pregnancies complicated with gestational thrombocytopenia (p = 0.041). Thrombocytopenia in previous pregnancy seems to be an important predicting factor for disease severity in the current pregnancy (p = 0.01).
Gestational thrombocytopenia, even if severe, is not associated with adverse maternal or neonatal outcome. Moderate neonatal thrombocytopenia is more common in pregnancies complicated with severe gestational thrombocytopenia. The incidence of severe gestational thrombocytopenia is higher in patients with thrombocytopenia in previous pregnancy.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>27418224</pmid><doi>10.5603/GP.2016.0025</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Croatia - epidemiology Female Gestational Age Humans Incidence Infant, Newborn Platelet Count - methods Pregnancy Pregnancy Complications, Hematologic - diagnosis Pregnancy Complications, Hematologic - epidemiology Risk Factors Severity of Illness Index Thrombocytopenia Thrombocytopenia - diagnosis Thrombocytopenia - epidemiology Thrombocytopenia - etiology Thrombocytopenia, Neonatal Alloimmune - diagnosis Thrombocytopenia, Neonatal Alloimmune - epidemiology Thrombocytopenia, Neonatal Alloimmune - etiology |
| title | Fetal-maternal complications and their association with gestational thrombocytopenia |
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