Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease
Purpose How changes in depression and anxiety and well-being may fluctuate with changes in disease-specific quality of life (QOL), and further how changes in wellbeing may fluctuate with changes in depression and anxiety among patients with moderate and severe chronic obstructive pulmonary disease (...
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| Veröffentlicht in: | Quality of life research 2016-08, Vol.25 (8), p.2041-2051 |
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| creator | Borge, Christine R. Mengshoel, Anne M. Moum, Torbjørn Wahl, Astrid K. |
| description | Purpose How changes in depression and anxiety and well-being may fluctuate with changes in disease-specific quality of life (QOL), and further how changes in wellbeing may fluctuate with changes in depression and anxiety among patients with moderate and severe chronic obstructive pulmonary disease (COPD). Methods In a longitudinal study (as part of a randomized controlled trial), we investigated 150 patients with moderate and severe COPD at baseline, 143 at 4 weeks, and 130 at 4 months. Lung function was tested, and a questionnaire was completed at all appointments. The questions captured demographic variables, disease-specific QOL (St. George's Respiratory Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), and wellbeing (World Health Organization-5 Well-being Index). Multiple regression analyses were performed. Results At 4 weeks and 4 months, changes in disease-specific QOL (st. β = -0.35, p < 0.001, partial (p) R² = 11-12 %), depression (st. β = -0.32 to -0.36, p < 0.001, pR² = 9-12 %), and anxiety (st. β = -0.21 to -0.40, p < 0.02-0.001, pR² = 4-15 %) were significantly associated with changes in well-being. Changes in disease-specific QOL were significantly associated with changes in anxiety at 4 months (st. β = 0.21, p = 0.02, pR² = 4 %), but not with changes in depression. Conclusions Changes in disease-specific QOL, depression, and anxiety were associated with changes in well-being. Changes in disease-specific QOL contributed slightly to changes in anxiety, but not to changes in depression. Wellbeing may capture some aspects of mental QOL in COPD patients better than depression and anxiety. |
| doi_str_mv | 10.1007/s11136-016-1227-4 |
| format | Article |
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Methods In a longitudinal study (as part of a randomized controlled trial), we investigated 150 patients with moderate and severe COPD at baseline, 143 at 4 weeks, and 130 at 4 months. Lung function was tested, and a questionnaire was completed at all appointments. The questions captured demographic variables, disease-specific QOL (St. George's Respiratory Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), and wellbeing (World Health Organization-5 Well-being Index). Multiple regression analyses were performed. Results At 4 weeks and 4 months, changes in disease-specific QOL (st. β = -0.35, p < 0.001, partial (p) R² = 11-12 %), depression (st. β = -0.32 to -0.36, p < 0.001, pR² = 9-12 %), and anxiety (st. β = -0.21 to -0.40, p < 0.02-0.001, pR² = 4-15 %) were significantly associated with changes in well-being. Changes in disease-specific QOL were significantly associated with changes in anxiety at 4 months (st. β = 0.21, p = 0.02, pR² = 4 %), but not with changes in depression. Conclusions Changes in disease-specific QOL, depression, and anxiety were associated with changes in well-being. Changes in disease-specific QOL contributed slightly to changes in anxiety, but not to changes in depression. Wellbeing may capture some aspects of mental QOL in COPD patients better than depression and anxiety.</description><identifier>ISSN: 0962-9343</identifier><identifier>EISSN: 1573-2649</identifier><identifier>DOI: 10.1007/s11136-016-1227-4</identifier><identifier>PMID: 26790426</identifier><language>eng</language><publisher>Cham: Springer</publisher><subject>Aged ; Anxiety ; Chronic obstructive pulmonary disease ; CLINICAL AND POLICY APPLICATIONS ; Clinical outcomes ; Clinical trials ; Data collection ; Depressive disorders ; Disease ; Female ; Health sciences ; Hospitals ; Humans ; Infections ; Longitudinal Studies ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Mental depression ; Mental health outcomes ; Psychological symptoms ; Public Health ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - psychology ; Quality of life ; Quality of Life Research ; Questionnaires ; Sickness Impact Profile ; Sociology ; Surveys and Questionnaires ; Symptoms ; Wellbeing</subject><ispartof>Quality of life research, 2016-08, Vol.25 (8), p.2041-2051</ispartof><rights>Springer International Publishing 2016</rights><rights>Springer International Publishing Switzerland 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-f4c2818fcbb05bf2c5b011c8faa0b752d0446f32f3c37830420c5b39689cd58d3</citedby><cites>FETCH-LOGICAL-c394t-f4c2818fcbb05bf2c5b011c8faa0b752d0446f32f3c37830420c5b39689cd58d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44852496$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44852496$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,41464,42533,51294,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26790426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borge, Christine R.</creatorcontrib><creatorcontrib>Mengshoel, Anne M.</creatorcontrib><creatorcontrib>Moum, Torbjørn</creatorcontrib><creatorcontrib>Wahl, Astrid K.</creatorcontrib><title>Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease</title><title>Quality of life research</title><addtitle>Qual Life Res</addtitle><addtitle>Qual Life Res</addtitle><description>Purpose How changes in depression and anxiety and well-being may fluctuate with changes in disease-specific quality of life (QOL), and further how changes in wellbeing may fluctuate with changes in depression and anxiety among patients with moderate and severe chronic obstructive pulmonary disease (COPD). Methods In a longitudinal study (as part of a randomized controlled trial), we investigated 150 patients with moderate and severe COPD at baseline, 143 at 4 weeks, and 130 at 4 months. Lung function was tested, and a questionnaire was completed at all appointments. The questions captured demographic variables, disease-specific QOL (St. George's Respiratory Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), and wellbeing (World Health Organization-5 Well-being Index). Multiple regression analyses were performed. Results At 4 weeks and 4 months, changes in disease-specific QOL (st. β = -0.35, p < 0.001, partial (p) R² = 11-12 %), depression (st. β = -0.32 to -0.36, p < 0.001, pR² = 9-12 %), and anxiety (st. β = -0.21 to -0.40, p < 0.02-0.001, pR² = 4-15 %) were significantly associated with changes in well-being. Changes in disease-specific QOL were significantly associated with changes in anxiety at 4 months (st. β = 0.21, p = 0.02, pR² = 4 %), but not with changes in depression. Conclusions Changes in disease-specific QOL, depression, and anxiety were associated with changes in well-being. Changes in disease-specific QOL contributed slightly to changes in anxiety, but not to changes in depression. Wellbeing may capture some aspects of mental QOL in COPD patients better than depression and anxiety.</description><subject>Aged</subject><subject>Anxiety</subject><subject>Chronic obstructive pulmonary disease</subject><subject>CLINICAL AND POLICY APPLICATIONS</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Data collection</subject><subject>Depressive disorders</subject><subject>Disease</subject><subject>Female</subject><subject>Health sciences</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Mental health outcomes</subject><subject>Psychological symptoms</subject><subject>Public Health</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - psychology</subject><subject>Quality of life</subject><subject>Quality of Life Research</subject><subject>Questionnaires</subject><subject>Sickness Impact Profile</subject><subject>Sociology</subject><subject>Surveys and Questionnaires</subject><subject>Symptoms</subject><subject>Wellbeing</subject><issn>0962-9343</issn><issn>1573-2649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQRi0EoreFB2ABssSGTcB_cewlqihFqsQG1pHjjG99lcS3HqdV34DHxlVKhViw8sLnO-PxR8gbzj5yxrpPyDmXumFcN1yIrlHPyI63nWyEVvY52TGrRWOlkifkFPHAGDOWiZfkROjOMiX0jvy6mFZfVlfisqdHVwrkBWlc6M3qpljuaQp0igFoWotPMyB1c9rQCEtBehfLNZ3TCNkVoG4ZKcItZKBY3L7iNe-vc1qip2nAkuu0eAv0uE7V4_I9HSOCQ3hFXgQ3Ibx-PM_Iz4svP84vm6vvX7-df75qvLSqNEF5YbgJfhhYOwTh24Fx7k1wjg1dK0amlA5SBOllZ2RdklVEWm2sH1szyjPyYfMec7pZAUs_R_QwTW6BtGLPDVNGy1bxir7_Bz2kNS_1dZWqX29Ma22l-Eb5nBAzhP6Y41w36znrH2rqt5r6WlP_UFOvaubdo3kdZhifEn96qYDYAKxXyx7yX6P_Y327hQ5YUn6SKmVaoayWvwGDc6lO</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Borge, Christine R.</creator><creator>Mengshoel, Anne M.</creator><creator>Moum, Torbjørn</creator><creator>Wahl, Astrid K.</creator><general>Springer</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease</title><author>Borge, Christine R. ; Mengshoel, Anne M. ; Moum, Torbjørn ; Wahl, Astrid K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-f4c2818fcbb05bf2c5b011c8faa0b752d0446f32f3c37830420c5b39689cd58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Anxiety</topic><topic>Chronic obstructive pulmonary disease</topic><topic>CLINICAL AND POLICY APPLICATIONS</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Data collection</topic><topic>Depressive disorders</topic><topic>Disease</topic><topic>Female</topic><topic>Health sciences</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Mental health outcomes</topic><topic>Psychological symptoms</topic><topic>Public Health</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - psychology</topic><topic>Quality of life</topic><topic>Quality of Life Research</topic><topic>Questionnaires</topic><topic>Sickness Impact Profile</topic><topic>Sociology</topic><topic>Surveys and Questionnaires</topic><topic>Symptoms</topic><topic>Wellbeing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borge, Christine R.</creatorcontrib><creatorcontrib>Mengshoel, Anne M.</creatorcontrib><creatorcontrib>Moum, Torbjørn</creatorcontrib><creatorcontrib>Wahl, Astrid K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Quality of life research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borge, Christine R.</au><au>Mengshoel, Anne M.</au><au>Moum, Torbjørn</au><au>Wahl, Astrid K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease</atitle><jtitle>Quality of life research</jtitle><stitle>Qual Life Res</stitle><addtitle>Qual Life Res</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>25</volume><issue>8</issue><spage>2041</spage><epage>2051</epage><pages>2041-2051</pages><issn>0962-9343</issn><eissn>1573-2649</eissn><abstract>Purpose How changes in depression and anxiety and well-being may fluctuate with changes in disease-specific quality of life (QOL), and further how changes in wellbeing may fluctuate with changes in depression and anxiety among patients with moderate and severe chronic obstructive pulmonary disease (COPD). Methods In a longitudinal study (as part of a randomized controlled trial), we investigated 150 patients with moderate and severe COPD at baseline, 143 at 4 weeks, and 130 at 4 months. Lung function was tested, and a questionnaire was completed at all appointments. The questions captured demographic variables, disease-specific QOL (St. George's Respiratory Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), and wellbeing (World Health Organization-5 Well-being Index). Multiple regression analyses were performed. Results At 4 weeks and 4 months, changes in disease-specific QOL (st. β = -0.35, p < 0.001, partial (p) R² = 11-12 %), depression (st. β = -0.32 to -0.36, p < 0.001, pR² = 9-12 %), and anxiety (st. β = -0.21 to -0.40, p < 0.02-0.001, pR² = 4-15 %) were significantly associated with changes in well-being. Changes in disease-specific QOL were significantly associated with changes in anxiety at 4 months (st. β = 0.21, p = 0.02, pR² = 4 %), but not with changes in depression. Conclusions Changes in disease-specific QOL, depression, and anxiety were associated with changes in well-being. Changes in disease-specific QOL contributed slightly to changes in anxiety, but not to changes in depression. Wellbeing may capture some aspects of mental QOL in COPD patients better than depression and anxiety.</abstract><cop>Cham</cop><pub>Springer</pub><pmid>26790426</pmid><doi>10.1007/s11136-016-1227-4</doi><tpages>11</tpages></addata></record> |
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| subjects | Aged Anxiety Chronic obstructive pulmonary disease CLINICAL AND POLICY APPLICATIONS Clinical outcomes Clinical trials Data collection Depressive disorders Disease Female Health sciences Hospitals Humans Infections Longitudinal Studies Male Medical research Medicine Medicine & Public Health Mental depression Mental health outcomes Psychological symptoms Public Health Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - psychology Quality of life Quality of Life Research Questionnaires Sickness Impact Profile Sociology Surveys and Questionnaires Symptoms Wellbeing |
| title | Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease |
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