Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a human disorder characterized by defective Fas signaling, resulting in chronic benign lymphoproliferation and accumulation of TCRαβ+ CD4− CD8− double-negative T (DNT) cells. Although their phenotype resembles that of terminally differentiated or exh...

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Veröffentlicht in:	Blood 2016-07, Vol.128 (2), p.227-238
Hauptverfasser:	Völkl, Simon, Rensing-Ehl, Anne, Allgäuer, Andrea, Schreiner, Elisabeth, Lorenz, Myriam Ricarda, Rohr, Jan, Klemann, Christian, Fuchs, Ilka, Schuster, Volker, von Bueren, André O., Naumann-Bartsch, Nora, Gambineri, Eleonora, Siepermann, Kathrin, Kobbe, Robin, Nathrath, Michaela, Arkwright, Peter D., Miano, Maurizio, Stachel, Klaus-Daniel, Metzler, Markus, Schwarz, Klaus, Kremer, Anita N., Speckmann, Carsten, Ehl, Stephan, Mackensen, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Autoimmune Lymphoproliferative Syndrome - immunology Autoimmune Lymphoproliferative Syndrome - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Differentiation - immunology Child Child, Preschool Female Humans Lectins, C-Type - immunology Leukocyte Common Antigens - immunology Male Proto-Oncogene Proteins c-akt - immunology Receptors, Antigen, T-Cell - immunology Receptors, Immunologic Signal Transduction - immunology TOR Serine-Threonine Kinases - immunology Trans-Activators - immunology
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