Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs

Our study aimed to target adenoviral gene therapy to the uteroplacental circulation of pregnant guinea pigs in order to develop a novel therapy for fetal growth restriction. Four methods of delivery of an adenovirus encoding β-galactosidase (Ad.LacZ) were evaluated: intravascular injection using pho...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2016-08, Vol.23 (8), p.1087-1095
Hauptverfasser:	Mehta, Vedanta, Ofir, Keren, Swanson, Anna, Kloczko, Ewa, Boyd, Michael, Barker, Hannah, Avdic-Belltheus, Adnan, Martin, John, Zachary, Ian, Peebles, Donald, David, Anna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - physiology Animals beta-Galactosidase - analysis beta-Galactosidase - genetics Embryology Enzyme-Linked Immunosorbent Assay Female Fetal Growth Retardation - therapy Gene Targeting - methods Genetic Therapy - methods Genetic Vectors - administration & dosage Guinea Pigs Iliac Artery Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Article Placental Circulation Pregnancy Radial Artery Reproductive Medicine Uterine Artery
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