A case of hyperkinetic movement disorder associated with LGI1 antibodies
Encephalitis associated with leucine-rich glioma inactivated 1 (LGI1) antibodies is often encountered in elderly male patients and may infrequently present with isolated syndromes. A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neur...
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| Veröffentlicht in: | Turkish journal of pediatrics 2015-09, Vol.57 (5), p.514-517 |
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| container_title | Turkish journal of pediatrics |
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| creator | Erer Özbek, Sevda Yapıcı, Zuhal Tüzün, Erdem Giriş, Murat Duran, Selcen Taşkapılıoğlu, Özlem Okan, Mehmet |
| description | Encephalitis associated with leucine-rich glioma inactivated 1 (LGI1) antibodies is often encountered in elderly male patients and may infrequently present with isolated syndromes. A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neurologic examination, he had repetitive and rhythmic movements in orolingual muscles including tongue protrusion, limb chorea and minimal facial stereotypic movements. Anti-streptolysin O (ASO) titers were found severely elevated in several measurements. Well-characterized antibodies against ion channels and synapse proteins were negative whereas LGI1 antibody was positive in both serum and CSF. Marked clinical improvement was observed after immunotherapy. Here, we present the first pediatric case with LGI1 antibody associated hyperkinetic movement disorders and emphasize the importance of investigating neuronal autoantibodies in patients with isolated and treatment resistant movement disorders. |
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A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neurologic examination, he had repetitive and rhythmic movements in orolingual muscles including tongue protrusion, limb chorea and minimal facial stereotypic movements. Anti-streptolysin O (ASO) titers were found severely elevated in several measurements. Well-characterized antibodies against ion channels and synapse proteins were negative whereas LGI1 antibody was positive in both serum and CSF. Marked clinical improvement was observed after immunotherapy. Here, we present the first pediatric case with LGI1 antibody associated hyperkinetic movement disorders and emphasize the importance of investigating neuronal autoantibodies in patients with isolated and treatment resistant movement disorders.</description><identifier>ISSN: 0041-4301</identifier><identifier>PMID: 27411421</identifier><language>eng</language><publisher>Turkey: Hacettepe University Faculty of Medicine</publisher><subject>Autoantibodies - blood ; Child ; Diagnosis, Differential ; Humans ; Hyperkinesis - diagnosis ; Hyperkinesis - immunology ; Leucine ; Male ; Proteins - immunology</subject><ispartof>Turkish journal of pediatrics, 2015-09, Vol.57 (5), p.514-517</ispartof><rights>Copyright Hacettepe University Faculty of Medicine Sep/Oct 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27411421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erer Özbek, Sevda</creatorcontrib><creatorcontrib>Yapıcı, Zuhal</creatorcontrib><creatorcontrib>Tüzün, Erdem</creatorcontrib><creatorcontrib>Giriş, Murat</creatorcontrib><creatorcontrib>Duran, Selcen</creatorcontrib><creatorcontrib>Taşkapılıoğlu, Özlem</creatorcontrib><creatorcontrib>Okan, Mehmet</creatorcontrib><title>A case of hyperkinetic movement disorder associated with LGI1 antibodies</title><title>Turkish journal of pediatrics</title><addtitle>Turk J Pediatr</addtitle><description>Encephalitis associated with leucine-rich glioma inactivated 1 (LGI1) antibodies is often encountered in elderly male patients and may infrequently present with isolated syndromes. A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neurologic examination, he had repetitive and rhythmic movements in orolingual muscles including tongue protrusion, limb chorea and minimal facial stereotypic movements. Anti-streptolysin O (ASO) titers were found severely elevated in several measurements. Well-characterized antibodies against ion channels and synapse proteins were negative whereas LGI1 antibody was positive in both serum and CSF. Marked clinical improvement was observed after immunotherapy. Here, we present the first pediatric case with LGI1 antibody associated hyperkinetic movement disorders and emphasize the importance of investigating neuronal autoantibodies in patients with isolated and treatment resistant movement disorders.</description><subject>Autoantibodies - blood</subject><subject>Child</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Hyperkinesis - diagnosis</subject><subject>Hyperkinesis - immunology</subject><subject>Leucine</subject><subject>Male</subject><subject>Proteins - immunology</subject><issn>0041-4301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0M9LwzAcBfAcFDen_4IEvHgp5Feb5DiGboOCFz2XNPmWZa5NTVJl_70F58XTu3x4PN4VWhIiaCE4oQt0m9KRECaJljdowaSgVDC6RLs1tiYBDh0-nEeIH36A7C3uwxf0MGTsfArRQcQmpWC9yeDwt88HXG_3FJsh-zY4D-kOXXfmlOD-kiv0_vL8ttkV9et2v1nXxci4zkVbUStLJrW0utOVo4KWHS0td5WWjHAlFZSgGEhHVVU6xYjSyjqrpeOEcb5CT7-9YwyfE6Tc9D5ZOJ3MAGFKDVVEqIrIUs_08R89hikO87pZzcVMCaFm9XBRU9uDa8boexPPzd9H_AfOB18X</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Erer Özbek, Sevda</creator><creator>Yapıcı, Zuhal</creator><creator>Tüzün, Erdem</creator><creator>Giriş, Murat</creator><creator>Duran, Selcen</creator><creator>Taşkapılıoğlu, Özlem</creator><creator>Okan, Mehmet</creator><general>Hacettepe University Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>A case of hyperkinetic movement disorder associated with LGI1 antibodies</title><author>Erer Özbek, Sevda ; 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A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neurologic examination, he had repetitive and rhythmic movements in orolingual muscles including tongue protrusion, limb chorea and minimal facial stereotypic movements. Anti-streptolysin O (ASO) titers were found severely elevated in several measurements. Well-characterized antibodies against ion channels and synapse proteins were negative whereas LGI1 antibody was positive in both serum and CSF. Marked clinical improvement was observed after immunotherapy. Here, we present the first pediatric case with LGI1 antibody associated hyperkinetic movement disorders and emphasize the importance of investigating neuronal autoantibodies in patients with isolated and treatment resistant movement disorders.</abstract><cop>Turkey</cop><pub>Hacettepe University Faculty of Medicine</pub><pmid>27411421</pmid><tpages>4</tpages></addata></record> |
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| subjects | Autoantibodies - blood Child Diagnosis, Differential Humans Hyperkinesis - diagnosis Hyperkinesis - immunology Leucine Male Proteins - immunology |
| title | A case of hyperkinetic movement disorder associated with LGI1 antibodies |
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