When Is It Appropriate to Use Arginine in Critical Illness?
In health, arginine is considered a nonessential amino acid but can become an essential amino acid (ie, conditionally essential amino acid) during periods of metabolic or traumatic stress as endogenous arginine supply is inadequate to meet physiologic demands. Arginine depletion in critical illness...
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| Veröffentlicht in: | Nutrition in Clinical Practice 2016-08, Vol.31 (4), p.438-444 |
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| container_title | Nutrition in Clinical Practice |
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| creator | Patel, Jayshil J. Miller, Keith R. Rosenthal, Cameron Rosenthal, Martin D. |
| description | In health, arginine is considered a nonessential amino acid but can become an essential amino acid (ie, conditionally essential amino acid) during periods of metabolic or traumatic stress as endogenous arginine supply is inadequate to meet physiologic demands. Arginine depletion in critical illness is associated with impairments in microcirculatory blood flow, impaired wound healing, and T-cell dysfunction. The purpose of this review is to (1) describe arginine metabolism and role in health and critical illness, (2) describe the relationship between arginine and asymmetric dimethylarginine, and (3) review studies of supplemental arginine in critically ill patients. |
| doi_str_mv | 10.1177/0884533616652576 |
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Arginine depletion in critical illness is associated with impairments in microcirculatory blood flow, impaired wound healing, and T-cell dysfunction. 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Arginine depletion in critical illness is associated with impairments in microcirculatory blood flow, impaired wound healing, and T-cell dysfunction. The purpose of this review is to (1) describe arginine metabolism and role in health and critical illness, (2) describe the relationship between arginine and asymmetric dimethylarginine, and (3) review studies of supplemental arginine in critically ill patients.</description><subject>arginase</subject><subject>arginine</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - deficiency</subject><subject>Arginine - metabolism</subject><subject>Arginine - therapeutic use</subject><subject>asymmetric dimethylarginine</subject><subject>Critical Care - methods</subject><subject>Critical Illness</subject><subject>Dietary Supplements</subject><subject>Humans</subject><subject>nitric oxide</subject><subject>Nursing</subject><subject>sepsis</subject><subject>surgery</subject><subject>trauma</subject><subject>wound healing</subject><issn>0884-5336</issn><issn>1941-2452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRbK3uXcks3UTnkXkEF1KCj0BRFxaXYTK5U1PSpGYSpP_ehFQXgri6i_Odw7kHoXNKrihV6ppoHQrOJZVSMKHkAZrSKKQBCwU7RNNBDgZ9gk68XxNCNVf6GE2YYoIxpabo5u0dKpx4nLR4vt029bYpTAu4rfHSA543q6IqKsBFheOmaAtrSpyUZQXe356iI2dKD2f7O0PL-7vX-DFYPD8k8XwRWK65DjICLKPO2UhQKxwLQ-I0FSLXNlIutyKLSA4uk1IZmxMnncsscMm1sswa4DN0Oeb29T468G26KbyFsjQV1J1PqSahFlIJ3aNkRG1Te9-AS_t_NqbZpZSkw2Tp78l6y8U-vcs2kP8YvjfqATECn0UJu38D06f4hYR86BKMPm9WkK7rrqn6lf4u8gWyIIG5</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Patel, Jayshil J.</creator><creator>Miller, Keith R.</creator><creator>Rosenthal, Cameron</creator><creator>Rosenthal, Martin D.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>When Is It Appropriate to Use Arginine in Critical Illness?</title><author>Patel, Jayshil J. ; Miller, Keith R. ; Rosenthal, Cameron ; Rosenthal, Martin D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3838-b0e2b1ffc951c5f2440f8155d8c97fdc5b90defb667acd0f6ffbce36387c2cae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>arginase</topic><topic>arginine</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - deficiency</topic><topic>Arginine - metabolism</topic><topic>Arginine - therapeutic use</topic><topic>asymmetric dimethylarginine</topic><topic>Critical Care - methods</topic><topic>Critical Illness</topic><topic>Dietary Supplements</topic><topic>Humans</topic><topic>nitric oxide</topic><topic>Nursing</topic><topic>sepsis</topic><topic>surgery</topic><topic>trauma</topic><topic>wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Jayshil J.</creatorcontrib><creatorcontrib>Miller, Keith R.</creatorcontrib><creatorcontrib>Rosenthal, Cameron</creatorcontrib><creatorcontrib>Rosenthal, Martin D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition in Clinical Practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Jayshil J.</au><au>Miller, Keith R.</au><au>Rosenthal, Cameron</au><au>Rosenthal, Martin D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>When Is It Appropriate to Use Arginine in Critical Illness?</atitle><jtitle>Nutrition in Clinical Practice</jtitle><addtitle>Nutr Clin Pract</addtitle><date>2016-08</date><risdate>2016</risdate><volume>31</volume><issue>4</issue><spage>438</spage><epage>444</epage><pages>438-444</pages><issn>0884-5336</issn><eissn>1941-2452</eissn><abstract>In health, arginine is considered a nonessential amino acid but can become an essential amino acid (ie, conditionally essential amino acid) during periods of metabolic or traumatic stress as endogenous arginine supply is inadequate to meet physiologic demands. Arginine depletion in critical illness is associated with impairments in microcirculatory blood flow, impaired wound healing, and T-cell dysfunction. The purpose of this review is to (1) describe arginine metabolism and role in health and critical illness, (2) describe the relationship between arginine and asymmetric dimethylarginine, and (3) review studies of supplemental arginine in critically ill patients.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27252277</pmid><doi>10.1177/0884533616652576</doi><tpages>7</tpages></addata></record> |
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| ispartof | Nutrition in Clinical Practice, 2016-08, Vol.31 (4), p.438-444 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | arginase arginine Arginine - analogs & derivatives Arginine - deficiency Arginine - metabolism Arginine - therapeutic use asymmetric dimethylarginine Critical Care - methods Critical Illness Dietary Supplements Humans nitric oxide Nursing sepsis surgery trauma wound healing |
| title | When Is It Appropriate to Use Arginine in Critical Illness? |
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