Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization

The importance of spatial organization in short peptide catalysts is well recognized. We synthesized and screened a library of peptides flanked by peptide nucleic acids (PNAs) such that the peptide would be constrained in a hairpin loop upon hybridization. A screen for phosphatase activity led to th...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-07, Vol.55 (30), p.8595-8598
Hauptverfasser:	Machida, Takuya, Dutt, Som, Winssinger, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	catalysis Hybridization Peptides Phosphatase PNA system chemistry
Online-Zugang:	Volltext
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